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I127

Sigma-Aldrich

ICI 118,551 hydrochloride

≥98% (HPLC), powder, β2 inverse agonist

Synonym(s):

(2R,3R)-rel-3-isopropylamino-1-(7-methylindan-4-yloxy)-butan-2-ol hydrochloride

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5 MG
¥38,850
25 MG
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About This Item

Empirical Formula (Hill Notation):
C17H27NO2 · HCl
CAS Number:
72795-01-8
Molecular Weight:
313.86
MDL number:
MFCD00153812
UNSPSC Code:
12352200
PubChem Substance ID:
24277782
NACRES:
NA.77

¥38,850

List Price¥55,500Save 30%

In StockDetails

Request a Bulk Order

Product Name

ICI 118,551 hydrochloride, ≥98% (HPLC), powder

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

H2O: >10 mg/mL

SMILES string

Cl.CC(C)N[C@@H](C)[C@@H](O)COc1ccc(C)c2CCCc12

InChI

1S/C17H27NO2.ClH/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17;/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3;1H/t13-,16-;/m0./s1

InChI key

KBXMBGWSOLBOQM-LINSIKMZSA-N

Gene Information

human ... ADRB2(154)

Application

ICI 118,551 hydrochloride has been used:
  • to block β-adrenergic signaling in various experiments[1][2]
  • to counteract degradation by endogenous T-lymphocyte monoamine oxidases[3]
  • to determine the specific receptor subtype necessary for isoproterenol to induce up-regulation of gene transcripts[4]

Biochem/physiol Actions

ICI 118,551 has been used to treat vasomotor migraines and somatic troubles related to anxiety state.[5]
ICI 118,551 hydrochloride is a highly selective β2-adrenoceptor antagonist.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Caution

Hygroscopic

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

I127-25MG:
I127-BULK:
I127-5MG:
I127-VAR:
I127-IP:

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Certificates of Analysis (COA)

Lot/Batch Number
0000249276
0000249276
0000035943
0000035943
0000023656

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R M Booze et al.
The Journal of pharmacology and experimental therapeutics, 249(3), 911-920 (1989-06-01)
The localization and number of beta adrenergic receptors were directly compared in the brains of rats and guinea pigs. The time course of association and saturability of [125I]cyanopindolol (CYP) binding to slide-mounted tissue sections was similar in rats (Kd =
Hongliang Li et al.
The Journal of biological chemistry, 288(42), 30734-30741 (2013-09-18)
Functional autoantibodies to the autonomic receptors are increasingly recognized in the pathophysiology of cardiovascular diseases. To date, no human activating monoclonal autoantibodies to these receptors have been available. In this study, we describe for the first time a β2-adrenergic receptor
Effect of chronic psychological stress on liver metastasis of colon cancer in mice
Zhao L, et al.
PLoS ONE, 10(10), e0139978-e0139978 (2015)
alpha-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway
Cai X, et al.
Faseb Journal, 32(1), 488-499 (2017)
Analysis of ICI 118551, a new beta2 blocking drug, and related compounds by RP-HPLC?DAD
Quaglia MG, et al.
Journal of Pharmaceutical and Biomedical Analysis, 10(10-12), 1081-1084 (1992)
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