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I1261

Sigma-Aldrich

Anti-Human IgA (α-chain specific) antibody produced in goat

whole antiserum

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About This Item

MDL number:
MFCD00162412
UNSPSC Code:
12352203
NACRES:
NA.46

biological source

goat

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

secondary antibodies

clone

polyclonal

contains

15 mM sodium azide

technique(s)

indirect ELISA: 1:50,000
quantitative precipitin assay: 3.0-5.0

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

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General description

Immunoglobulin A (IgA) is found as two subclasses, that is, IgA1 and IgA2. IgA exists as a monomer or dimer in the secreted form. Dimeric IgA has a molecular weight of 390 kDa.

Specificity

The antibody preparation is specific for human IgA when tested against purified human IgA, IgG, IgM, Bence Jones Kappa, and Bence Jones Lambda myeloma proteins

Application

Anti-Human IgA (α-chain specific) antibody produced in goat has been used to determine the concentration of total IgA in serum samples by single radial immunodiffusion and enzyme-linked immunosorbent assay (ELISA).

Biochem/physiol Actions

IgA antibody is secretory antibody and is present abundantly in mucous linings of gastrointestinal, respiratory and genitourinary tracts, tears and saliva. Thus secretory IgA contributes to the humoral defense mechanism against the pathogens on mucosal surfaces.
In addition to passive immunity, IgA also induces active immunity by regulating the production of various chemokines and vital cytokines such as tumor necrosis factor (TNF) and interleukin (IL)-1β.

Physical form

Goat Anti-Human IgA is supplied as a liquid containing 0.1% sodium azide as preservative.

Storage and Stability

For continuous use, store at 2-8 °C for a maximum of one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

I1261-VAR:
I1261-2ML:
I1261-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ivo S Hansen et al.
Cellular and molecular life sciences : CMLS, 76(6), 1041-1055 (2018-12-01)
The prevailing concept regarding the immunological function of immunoglobulin A (IgA) is that it binds to and neutralizes pathogens to prevent infection at mucosal sites of the body. However, recently, it has become clear that in humans IgA is also
Kinetic Analysis of Interaction of Different Types of Rheumatoid Factors with Immobilized IgG Using Surface PlasmonResonance
Matsumoto A, et al.
The Journal of Biological Chemistry, 128(6), 1009-1016 (2000)
Eva Michaud et al.
EMBO molecular medicine, 14(8), e15386-e15386 (2022-07-06)
Human secretory immunoglobulins (SIg) A1 and SIgA2 guide mucosal responses toward tolerance or inflammation, notably through reverse-transcytosis, the apical-to-basal transport of IgA2 immune complexes via M cells of gut Peyer's patches. As such, the maintenance of a diverse gut microbiota
L C Torres et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 43(12), 1215-1224 (2010-11-19)
Rubinstein-Taybi syndrome (RTS) is a rare developmental disorder characterized by craniofacial dysmorphisms, broad thumbs and toes, mental and growth deficiency, and recurrent respiratory infections. RTS has been associated with CREBBP gene mutations, but EP300 gene mutations have recently been reported
Guy Gorochov et al.
JAMA network open, 7(4), e248051-e248051 (2024-04-23)
There is still considerable controversy in the literature regarding the capacity of intramuscular messenger RNA (mRNA) vaccination to induce a mucosal immune response. To compare serum and salivary IgG and IgA levels among mRNA-vaccinated individuals with or without previous SARS-CoV-2
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