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Safety Information

H8004

Sigma-Aldrich

16α-Hydroxyestrone

≥99% (HPLC)

Synonym(s):

1,3,5(10)-Estratriene-3,16α-diol-17-one, 16α-3,16-Dihydroxyestra-1,3,5(10)-trien-17-one

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About This Item

Empirical Formula (Hill Notation):
C18H22O3
CAS Number:
566-76-7
Molecular Weight:
286.37
MDL number:
MFCD00870436
UNSPSC Code:
12352200
PubChem Substance ID:
24895817

Assay

≥99% (HPLC)
~95% (TLC)

SMILES string

C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1C[C@@H](O)C2=O

InChI

1S/C18H22O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-16,19-20H,2,4,6-7,9H2,1H3/t13-,14-,15+,16+,18-/m0/s1

InChI key

WPOCIZJTELRQMF-UJHHCITNSA-N

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Product No.
Description
Pricing

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H351,H360D,H362

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

H8004-BULK:
H8004-10MG:
H8004-5MG:
H8004-1MG:
H8004-VAR:
H8004-50MG:
H8004-25MG:

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Certificates of Analysis (COA)

Lot/Batch Number
087K4095
067K4061
092K4109
069H4025
063K4089

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Michael Wacker et al.
Journal of women's health (2002), 18(4), 487-491 (2009-04-14)
Hispanic women are at lower risk for incident breast cancer, but the reasons for this lower risk are unknown. Among postmenopausal women, breast cancer risk is inversely associated with circulating levels of 2-hydroxyestrone but directly associated with levels of 16alpha-hydroxyestrone
Susan R Sturgeon et al.
Nutrition and cancer, 62(2), 175-180 (2010-01-26)
Flaxseed is a rich source of dietary lignans. It has been hypothesized that lignans may decrease breast cancer risk through modulation of endogenous hormone levels. The aim of this study was to determine the effect of flaxseed supplementation on urinary
MaryFran R Sowers et al.
Arthritis and rheumatism, 54(8), 2481-2487 (2006-07-28)
To determine if levels of endogenous estrogen or estrogen metabolites are associated with an increased risk of developing knee osteoarthritis (OA) in women. Serum estradiol (E2) and 2 urinary estrogen metabolites (2-hydroxyestrone and 16alpha-hydroxyestrone) with radiographically defined prevalent and incident
Christophe Stavrakakis et al.
Journal of AOAC International, 91(1), 237-246 (2008-04-02)
This paper presents an analytical method applied to the determination of 3 natural steroid hormones, estrone, 17 beta-estradiol, and 16 alpha-hydroxyestrone, and the contraceptive estrogen, 17 alpha-ethynylestradiol, at the sub-ng/L level in water samples [surface water and wastewater treatment plant
MaryFran R Sowers et al.
The Journal of nutrition, 136(6), 1588-1595 (2006-05-17)
Diet and lifestyle factors, body size, and smoking behavior may influence estrogen metabolism, but the nature of these relations may vary according to race/ethnic groups. We evaluated the association of lifestyle factors with estrogen metabolites 2-hydroxyestrone (2-OHE1) and 16alpha-hydroxyestrone (16alpha-OHE1)
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