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Key Documents

Safety Information

H7158

Sigma-Aldrich

Heat Shock Protein 60 human

recombinant, expressed in E. coli, buffered aqueous solution, ≥95% (SDS-GE)

Synonym(s):

HSP 60

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About This Item

UNSPSC Code:
12352202

biological source

human

recombinant

expressed in E. coli

Assay

≥95% (SDS-GE)

form

buffered aqueous solution

UniProt accession no.

P10809

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... HSPD1(3329)

General description

The gene HSP60 (heat shock protein 60) is mapped to human chromosome 2q33.1. It is a mitochondrial protein. HSP60 is induced under various stress conditions, including DNA damage, oxidative stress and heat shock. HSP60 is also referred to as HSPD1 (heat shock protein family D member 1).

Biochem/physiol Actions

HSP60 (heat shock protein) works together with the cochaperonin HSP10 to allow protein folding of mitochondrial-imported proteins. It is involved in brain myelination and pathogenesis of hypomyelinating neurodegenerative disease. It also enhances proinflammatory response in cells, including macrophages, dendritic cells and endothelial cells. Mutation in HSP60 is linked with hereditary spastic paraplegia (SPG13).

Physical form

Solution in Dulbecco′s buffered saline

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

H7158-VAR:
H7158-.1MG-PW:
H7158-BULK:
H7158-.1MG:

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Certificates of Analysis (COA)

Lot/Batch Number
SLBF7531
SLBD7243
019K1354
068K1505
107K1531

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Piotr Bodzek et al.
Journal of ovarian research, 7, 30-30 (2014-03-13)
The aim of this study was to evaluate the concentrations of IgG antibodies against Hsp60 and Hsp65 in sera of patients with ovarian cancer at various stages of clinical progress and for different histopathological types of disease. Serum samples from
Antonella Marino Gammazza et al.
Scientific reports, 5, 9434-9434 (2015-03-25)
The mitochondrial chaperonin Hsp60 is a ubiquitous molecule with multiple roles, constitutively expressed and inducible by oxidative stress. In the brain, Hsp60 is widely distributed and has been implicated in neurological disorders, including epilepsy. A role for mitochondria and oxidative
Davide Seveso et al.
Diseases of aquatic organisms, 115(1), 15-23 (2015-06-30)
Brown band disease (BrB), a virulent coral disease characterized by a dense concentration of ciliates ingesting coral tissue, is responsible for ongoing coral losses on Indo-Pacific reefs. Although several efforts have been made to identify the microbial communities associated with
S Jindal et al.
Molecular and cellular biology, 9(5), 2279-2283 (1989-05-01)
The complete cDNA for a human mitochondrial protein designated P1, which was previously identified as a microtubule-related protein, has been cloned and sequenced. The deduced amino acid sequence of P1 shows strong homology (40 to 50% identical residues and an
Daniella Magen et al.
American journal of human genetics, 83(1), 30-42 (2008-06-24)
Hypomyelinating leukodystrophies (HMLs) are disorders involving aberrant myelin formation. The prototype of primary HMLs is the X-linked Pelizaeus-Merzbacher disease (PMD) caused by mutations in PLP1. Recently, homozygous mutations in GJA12 encoding connexin 47 were found in patients with autosomal-recessive Pelizaeus-Merzbacher-like
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