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Safety Information

H4397

Sigma-Aldrich

TiterMax® Classic Adjuvant

liquid

Synonym(s):

Adjuvant System, TiterMax Adjuvant

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.46

form

liquid

Quality Level

availability

not available in Japan

storage temp.

2-8°C

General description

The effectiveness of an oil emulsion vaccine greatly depends on the form and stability of the emulsion. TiterMax Classic is a water-in-oil formulation with up to 90% water and a powerful adjuvant used in many protocols. TiterMax Classic Adjuvant contains three essential ingredients: a block copolymer, CRL89-41, squalene (a metabolizable oil) and a unique microparticulate stabilizer. The emulsion is less viscous and suitable for injection through small needles.

Application

For mice, four doses of 10 microl each into subcutaneous or muscular sites is recommended. TiterMax® was used in mice followed by isolation of CD4 T cells for epitope mapping and to test vaccines against Neisseria species.
TiterMax® Classic Adjuvant has been used to boost the production of antigen-specific polyclonal IgG in rabbits.

Biochem/physiol Actions

TiterMax Classic has been especially formulated with squalene to produce stable water-in-oil emulsions with up to 90% water. It is considerably easier to emulsify TiterMax Classic than Freund′s adjuvant. The resulting emulsion is less viscous, making it easier to inject through small needles.

Legal Information

TiterMax is a registered trademark of TiterMax USA, Inc

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

H4397-.5ML:
H4397-VAR:
H4397-.5ML-PW:
H4397-BULK:


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Preclinical efficacy and immunogenicity assessment to show that a chimeric Plasmodium falciparum UB 05-09 antigen could be a malaria vaccine candidate
Dinga JN, et al.
Parasite Immunology, 40(3), e12514-e12514 (2018)
A A Delvig et al.
Methods in molecular medicine, 66, 349-360 (2001-01-01)
The majority of T cells recognize peptide epitopes bound to major histocompatibility complex (MHC)-encoded glycoproteins on the surface of professional antigen-presenting cells (APC), principally dendritic cells, macrophages, and B cells (1-3). Most T cells are specific for peptide epitopes in
A A Delvig et al.
Methods in molecular medicine, 66, 199-221 (2001-01-01)
Proteins with intrinsic mitogenic properties are widely represented in prokaryotes, such as in different Streptococcus species (1-3), Candida albicans (4), and Eikenella corrodens (5). Specifically, several bacterial porins of Escherichia coli, Shigella dysenteriae, Salmonella typhimurium, Fusobacterium nucleatum, and pathogenic Neisseria

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