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H3666

Sigma-Aldrich

HIPK4, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

FLJ32818

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

200

product line

PRECISIO® Kinase

Assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

172-232 nmol/min·mg

mol wt

~110 kDa

UniProt accession no.

Q8NE63

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... HIPK4(147746)

General description

HIPK4 (homeodomain-interacting protein kinase 4) is present in the lungs and white adipose tissues. The protein mainly localizes in the cytoplasm. However, a weak signal is also present in the nucleus.

Biochem/physiol Actions

HIPK4 (homeodomain-interacting protein kinase 4) is serine/threonine kinase protein. HIPK4-mediated phosphorylation of p53 is crucial for p53-associated transcriptional repression.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Cartagena Act

Cartagena Act Listed

JAN Code

H3666-10UG-PW:
H3666-VAR:
H3666-BULK:
H3666-10UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Valeria Di Stefano et al.
Experimental cell research, 293(2), 311-320 (2004-01-20)
HIPK2 is a member of a novel family of nuclear serine-threonine kinases identified through their ability to interact with the Nkx-1.2 homeoprotein. The physiological role of these kinases is largely unknown, but we have recently reported on the involvement of
Shigeki Arai et al.
FEBS letters, 581(29), 5649-5657 (2007-11-21)
We describe here the cloning and characterization of a novel mouse homeodomain-interacting protein kinase (HIPK)-like gene, Hipk4. Hipk4 is expressed in lung and in white adipose tissue and encodes a 616 amino acid protein that includes a serine/threonine kinase domain.

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