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H0266

Sigma-Aldrich

Hemoglobin A2, Ferrous Stabilized human

lyophilized powder

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5 MG
¥89,200

¥89,200

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5 MG
¥89,200

About This Item

CAS Number:
9034-53-1
EC Number:
232-897-1
MDL number:
MFCD00131286
UNSPSC Code:
12352202
eCl@ss:
42030116
NACRES:
NA.61

¥89,200

Available to ship onApril 14, 2025Details

Request a Bulk Order

biological source

human

Quality Level

200

Assay

97-100% (agarose gel electrophoresis)

form

lyophilized powder

technique(s)

immunofluorescence: suitable

suitability

suitable for electrophoresis and chromatography standard

UniProt accession no.

P69905

storage temp.

−20°C

Gene Information

human ... HBA2(3040)

General description

Hemoglobin A2 (HBA2) is mapped to human chromosome 16p13.3.[1] HBA2 is a minor hemoglobin component and comprises of two α and δ chains.[2]
Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.
has not been tested for functional equivalence against native preparations (unlyophilized ferrous hemoglobins).

Application

Hemoglobin A2 was used in the determination of fetal hemoglobin by time-resolved immunofluorometric assay.[3]
Hemoglobin A2, Ferrous Stabilized human has been used as a reference in reversed-phase high-performance liquid chromatography for quantifying δ-globin elution profile.[4] It has also been used as calibrator in isotope dilution mass spectrometry (IDMS) measurements.[5]

Biochem/physiol Actions

Elevated levels of Hemoglobin A2 (HBA2) is observed in patients with β-thalassemia trait.[2]

Packaging

Package size indicates the amount of hemoglobin as determined by the procedure of Drabkin, D.L., J. Biol. Chem., 164, 703 (1946).

Reconstitution

When reconstituted with buffer, gives >90% ferrous hemoglobin.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

H0266-BULK-N:
H0266-25MG:
H0266PROC:
H0266-5MG-PW:
H0266-BULK:
H0266-1MG:
H0266-5MG:
H0266-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
SLCM0613
SLCG0338
SLBR2604V
SLBK8749V
066K7575

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Dominant β-thalassemia - a rare entity!
Rachna Khera et al.
Indian journal of pathology & microbiology, 55(3), 422-423 (2012-10-04)
Domenico Dell'Edera et al.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 26(5), 445-448 (2012-10-09)
This research, conducted on 1495 couples in preconceptional period, demonstrates how the study of globular resistance of erythrocytes (GRO) is not a first choice test and not useful as other more accurate tests to identify subjects with β-thalassemia trait. Instead
Hb Dartmouth (HBA2: c. 200T> C): An alpha2-globin gene associated with Hb H disease in one homozygous patient
Farashi S, et al.
Hemoglobin, 39(3), 152-155 (2015)
Stacy Colaco et al.
Clinica chimica acta; international journal of clinical chemistry, 413(19-20), 1705-1707 (2012-06-05)
An increased HbA2 level is the hallmark for identification of β thalassemia carriers. However, in some carriers the level of HbA2 is not typically elevated creating difficulties in making a diagnosis. We describe a family having an affected child referred
Alauddin Hafiza et al.
The Malaysian journal of pathology, 34(2), 161-164 (2013-02-22)
The capillary electrophoresis (CE) is a new system that utilizes the principle of electrokinetic separation of molecules in eight electrolyte buffer-filled silica capillaries. In this study, we established the normal ranges of haemoglobin A2 (HbA2) and haemoglobin F (HbF) levels
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