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Safety Information

G8378

Sigma-Aldrich

Guanosine 5′-tetraphosphate tris salt

from Saccharomyces cerevisiae, ~95%

Synonym(s):

G-tetra-P

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About This Item

Empirical Formula (Hill Notation):
C10H17N5O17P4
CAS Number:
103213-27-0
Molecular Weight:
603.16
MDL number:
MFCD00058646
UNSPSC Code:
41106305
PubChem Substance ID:
329799979

biological source

Saccharomyces cerevisiae

Assay

~95%

form

solid

shipped in

dry ice

storage temp.

−20°C

SMILES string

NC(CO)(CO)CO.NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H17N5O17P4.C4H11NO3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(29-9)1-28-34(22,23)31-36(26,27)32-35(24,25)30-33(19,20)21;5-4(1-6,2-7)3-8/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H,26,27)(H2,19,20,21)(H3,11,13,14,18);6-8H,1-3,5H2/t3-,5-,6-,9-;/m1./s1

InChI key

ZEHPDAAYQIAYON-GWTDSMLYSA-N

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Biochem/physiol Actions

Guanosine 5′-tetraphosphate (G-tetra-P) may be used as a substrate to study the specificity and kinetics of polyphosphatases (triphosphate tunnel metalloenzymes (TTMs)) and exopolyphosphatases. Also used as an inhibitor to study the kinetics and mechanism of various guanylate cyclases. Guanosine 5′-tetraphosphate may be used in various studies with adenosine-5′-tetraphosphate.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H371

Hazard Classifications

STOT SE 2

Target Organs

Eyes,Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

G8378-BULK:
G8378-VAR:
G8378-25MG:
G8378-10MG:
G8378-5MG:4548174016305

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Certificates of Analysis (COA)

Lot/Batch Number
085K7026
094K7037
066H7820
065H7805
049H7024

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Faylene A Lunn et al.
The Journal of biological chemistry, 283(4), 2010-2020 (2007-11-16)
Cytidine 5'-triphosphate synthase catalyzes the ATP-dependent formation of CTP from UTP using either NH(3) or l-glutamine (Gln) as the source of nitrogen. GTP acts as an allosteric effector promoting Gln hydrolysis but inhibiting Gln-dependent CTP formation at concentrations of >0.15
T V Kulakovskaya et al.
Biochemistry. Biokhimiia, 62(9), 1051-1052 (1998-02-11)
A cytosolic preparation of Saccharomyces cerevisiae is capable of hydrolyzing adenosine-5'-tetraphosphate and guanosine-5'-tetraphosphate with activities which are 1.5-2 times greater than that with polyP15. The apparent K(m) values for hydrolysis of adenosine-5'-tetraphosphate and guanosine-5'-tetraphosphate are 100 and 80 microM, respectively.
Jianmin Fang et al.
The Journal of biological chemistry, 282(44), 32501-32510 (2007-09-11)
We report the cloning, expression, purification, and characterization of the Trypanosoma cruzi exopolyphosphatase (TcPPX). The product of this gene (TcPPX), has 383 amino acids and a molecular mass of 43.1 kDa. TcPPX differs from most exopolyphosphatases in its preference for
Ruchi Jain et al.
The Journal of biological chemistry, 283(45), 31047-31057 (2008-09-11)
Triphosphate tunnel metalloenzymes (TTMs) are a superfamily of phosphotransferases with a distinctive active site located within an eight-stranded beta barrel. The best understood family members are the eukaryal RNA triphosphatases, which catalyze the initial step in mRNA capping. The RNA
A Garger et al.
Visual neuroscience, 18(4), 625-632 (2002-02-07)
The second messenger systems involved in the final stages of the phototransduction cascade in Limulus photoreceptors remain unclear. Excised patches of transducing membrane contain cGMP-gated channels, suggesting the involvement of cGMP in the excitation process. To further explore this possibility

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