G5171

Anti-Granulocyte Colony Stimulating Factor antibody produced in goat

IgG fraction of antiserum, lyophilized powder

• Synonym(s): Anti-G-CSF
• MDL number: MFCD00211951
• UNSPSC Code: 51111800
• NACRES: NA.41

Properties

• biological source: goat
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• species reactivity: human
• technique(s): neutralization: suitable; western blot: 1-2 μg/mL
• UniProt accession no.: P09919
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CSF3(1440)

Description

General description

Mature myeloid cells are derived from bone-marrow derived precursor cells by the activity of three colony stimulating factors, granulocyte/macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF) and granulocyte colony-stimulating factor (G-CSF). The expression of G-CSF is the result of activation of pathways in response to tumor necrosis factor-α, LPS and toll-like receptor ligands. The pathways that induce the effects of G-CSF are PI3K, ERK1/2 and p38. The generation of neutrophils and induction of the circulation of hematopoietic stem cells from the bone marrow are the main functions of G-CSF. There are additional activities attributed to G-CSF such as neuroprotection, immunomodulation and generation of cardiac cells and dendritic cells. Large quantities of G-CSF are secreted in a variety of myeloid and non-myeloid cancers and rheumatoid arthritis
Monoclonal anti-granulocyte colony stimulating factor recognizes human G-CSF.

Immunogen

purified, recombinant human granulocyte colony stimulating factor, expressed in E. coli.

Application

Anti-granulocyte colony stimulating factor antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. The antibody is also suitable for neutralization assays.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves