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Safety Information

G4877

Sigma-Aldrich

Gonadotropin from pregnant mare serum

≥1,000 IU/mg

Synonym(s):

Equine gonadotropin, PMSG, Pregnant mare serum gonadotropin, eCG

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About This Item

CAS Number:
9002-70-4
EC Number:
232-663-9
MDL number:
MFCD01779765
UNSPSC Code:
12352202

form

powder

specific activity

≥1,000 IU/mg

mol wt

49- 68.5 kDa

solubility

water: 1 mg/mL, clear to slightly hazy, colorless to faintly yellow

storage temp.

−20°C

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General description

Gonadotropin hormone is only found in primates and is a member of the glycoprotein hormone family, which also consists of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH). This hormone is composed of two non-covalently linked α and β subunits. The α-subunits within a species are identical, whereas the β subunits are different, which confers the differences in physiological specificity.

Application

Gonadotropin from pregnant mare serum has been used-
  • for inducing superovulation in female Sprague Dawley rats
  • for injection in female golden hamster to eventually obtain zona-free hamster eggs

Biochem/physiol Actions

Gonadotropin interacts with members of the GPCR (G-protein coupled receptor family), and upon activation they induce adenylyl cyclase.
Human chorionic gondadotropin (hCG) may be used as an alternative to PMSG to induce ovulation in laboratory animals. When hCG was injected into laboratory animals via intravenous (i.v.), intraperitoneal (i.p.), or subcutaneous (s.c.) methodstet, the effective dose values for 50% of the animals (ED50) per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.

Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.
Two chain glycoprotein hormone; stimulates the growth of ovarian follicles and the formation of the corpus luteum.

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Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

G4877-PH:
G4877-1000IU-PW:
G4877-VAR:
G4877-10000IU:
G4877-BULK:
G4877-10000IU-PW:
G4877-2000IU:
G4877-1000IU:
G4877-PPG:
G4877-2000IU-PW:

Certificates of Analysis (COA)

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P H Chan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(20), 8292-8299 (1998-10-08)
Transient global cerebral ischemia resulting from cardiac arrest is known to cause selective death in vulnerable neurons, including hippocampal CA1 pyramidal neurons. It is postulated that oxygen radicals, superoxide in particular, are involved in cell death processes. To test this
Rafael Herrera Alvarez et al.
Journal of veterinary science, 17(4), 459-465 (2016-06-15)
Ovarian stimulation with commercial preparations of equine chorionic gonadotropin (eCG) produces extremely variable responses in domestic animals, ranging from excessive stimulation to practically no stimulation, when applied on the basis of their declared unitage. This study was conducted to analyze
W F Rall et al.
Journal of reproduction and fertility, 101(3), 681-688 (1994-08-01)
A vitrification solution consisting of 6.5 mol glycerol l-1 and 6% (w/v) BSA in a modified Dulbecco's PBS (designated solution VS3a) was examined for the cryopreservation of 8-12-cell mouse embryos. Solution VS3a vitrified when cooled to -196 degrees C at
Mario Plaas et al.
Scientific reports, 7(1), 10220-10220 (2017-09-02)
Wolfram syndrome (WS) is a rare autosomal-recessive disorder that is caused by mutations in the WFS1 gene and is characterized by juvenile-onset diabetes, optic atrophy, hearing loss and a number of other complications. Here, we describe the creation and phenotype
M S Roberson et al.
Molecular and cellular biology, 15(7), 3531-3539 (1995-07-01)
Gonadotropin-releasing hormone (GnRH) interacts with a G protein-coupled receptor and increases the transcription of the glycoprotein hormone alpha-subunit gene. We have explored the possibility that mitogen-activated protein kinase (MAPK) plays a role in mediating GnRH effects on transcription. Activation of
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