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G3670

Sigma-Aldrich

Galectin-8 from rat

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

Gal-8, Po66 carbohydrate-binding protein, Prostate carcinoma tumor antigen 1

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About This Item

MDL number:
MFCD07785205
UNSPSC Code:
12352202

biological source

rat

recombinant

expressed in E. coli

Assay

≥90% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

protein 34 kDa

packaging

pkg of 100 μg

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

Q62665

shipped in

dry ice

storage temp.

−20°C

Gene Information

rat ... Lgals8(116641)

General description

Galectin-8 is one of the β-galactoside-binding lectins called galectins, which reside in the cytosol before being released in a signal sequence-independent pathway.

Biochem/physiol Actions

Galectin-8 functions as a danger receptor and thus, prevents the proliferation of Salmonella. It detects host glycans found on the surface of damaged Salmonella-containing vacuoles. It also maintains the endo-lysosomal integrity. This protein prevents the adhesion of human carcinoma cells to integrin-ligand coated plates. This results in induction of apoptosis.
Galectin-8 is a family member of animal lectins which selectively binds β-galactoside residues. It is a widely expressed 34 kDa protein, which is secreted by many cell types. Galectin-8 is made of two homol­o­gous regions, each having a single carbohydrate recognition domain (CRD), linked by a short peptide. Galectin-8 acts as a physiological modulator of cell adhesion and cellular growth, and may be involved in neoplastic transformation.

Physical form

Solution containing 20 mM Tris, pH 7.4, 1 mM DTT, 1 mM EDTA, and 30% glycerol.

Analysis Note

The biological activity is measured by its ability to agglutinate human red cells.

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Description
Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

G3670-VAR:
G3670-100UG:
G3670-BULK:

Certificates of Analysis (COA)

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Osamu Suzuki et al.
International journal of oncology, 46(3), 973-980 (2015-01-13)
The interaction between cell surface glycans and extracellular matrix (ECM) including galectins is known to be closely associated with tumor cell adhesion, invasion and metastasis. We analyzed the roles of cell surface sialylation or glycosylation in galectin or ECM‑mediated cell
Teresa L M Thurston et al.
Nature, 482(7385), 414-418 (2012-01-17)
Autophagy defends the mammalian cytosol against bacterial infection. Efficient pathogen engulfment is mediated by cargo-selecting autophagy adaptors that rely on unidentified pattern-recognition or danger receptors to label invading pathogens as autophagy cargo, typically by polyubiquitin coating. Here we show in
I Camby et al.
Brain pathology (Zurich, Switzerland), 11(1), 12-26 (2001-01-06)
Galectins, a family of mammalian lectins with specificity to beta-galactosides, are involved in growth-regulatory mechanisms and cell adhesion. A relationship is assumed to exist between the levels of expression of galectins and the level of malignancy in human gliomas. A
Y Levy et al.
The Journal of biological chemistry, 276(33), 31285-31295 (2001-05-24)
The interaction of cells with the extracellular matrix regulates cell adhesion and motility. Here we demonstrate that different cell types adhere and spread when cultured in serum-free medium on immobilized galectin-8, a mammalian beta-galactoside-binding protein. At maximal doses, galectin-8 is
Y R Hadari et al.
Journal of cell science, 113 ( Pt 13), 2385-2397 (2000-06-15)
The interaction of cells with the extracellular matrix regulates cell adhesion, motility, growth, survival and differentiation through integrin-mediated signal transduction. Here we demonstrate that galectin-8, a secreted mammalian (beta)-galactoside binding protein, inhibits adhesion of human carcinoma (1299) cells to plates

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