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Safety Information

G1506

Sigma-Aldrich

Guanylyl(3′→5′)cytidine ammonium salt

Synonym(s):

GpC

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About This Item

Linear Formula:
C19H25N8O12P · NH3
CAS Number:
98046-67-4
Molecular Weight:
605.45
MDL number:
MFCD00058649
UNSPSC Code:
41106305
PubChem Substance ID:
24895064

form

solid

storage temp.

−20°C

SMILES string

N.NC1=NC(=O)c2ncn(C3OC(CO)C(OP(O)(=O)OCC4OC(C(O)C4O)N5C=CC(N)=NC5=O)C3O)c2N1

InChI

1S/C19H25N8O12P.H3N/c20-8-1-2-26(19(33)23-8)16-11(30)10(29)7(38-16)4-36-40(34,35)39-13-6(3-28)37-17(12(13)31)27-5-22-9-14(27)24-18(21)25-15(9)32;/h1-2,5-7,10-13,16-17,28-31H,3-4H2,(H,34,35)(H2,20,23,33)(H3,21,24,25,32);1H3

InChI key

PPSONIOCBRREER-UHFFFAOYSA-N

Application

Guanylyl(3′5′)cytidine is an oligonucleotide pyrimidine dimer used as a substrate to study the specificity and kinetics of various RNases such as RNase T1 and its mutations.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

G1506-1MG:
G1506-VAR:
G1506-BULK:
G1506-5MG:

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Certificates of Analysis (COA)

Lot/Batch Number
012H7832

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Rico Czaja et al.
Biochemistry, 43(10), 2854-2862 (2004-03-10)
Attempts to alter the guanine specificity of ribonuclease T1 (RNase T1) by rational or random mutagenesis have failed so far. The RNase T1 variant RV (Lys41Glu, Tyr42Phe, Asn43Arg, Tyr45Trp, and Glu46Asn) designed by combination of a random and a rational
Marc Struhalla et al.
Chembiochem : a European journal of chemical biology, 5(2), 200-205 (2004-02-05)
Although ribonuclease T1 (RNase T1) is one of the best-characterized proteins with respect to structure and enzymatic action, numerous attempts at altering the specificity of the enzyme to cleave single-stranded RNA at the 3'-side of adenylic instead of guanylic residues
Alexandra Søgaard Helbo et al.
Scientific reports, 7, 41947-41947 (2017-02-09)
Chromatin is structurally involved in the transcriptional regulation of all genes. While the nucleosome positioning at RNA polymerase II (pol II) promoters has been extensively studied, less is known about the chromatin structure at pol III promoters in human cells.
Martin Vincent et al.
Genome biology, 18(1), 38-38 (2017-02-23)
The study of epigenetic heterogeneity at the level of individual cells and in whole populations is the key to understanding cellular differentiation, organismal development, and the evolution of cancer. We develop a statistical method, epiG, to infer and differentiate between
Ilona Telefus Goldfarb et al.
Reproductive sciences (Thousand Oaks, Calif.), 25(5), 788-796 (2017-09-09)
While there is evidence for a relationship between cell-free fetal DNA (cffDNA) and parturition, questions remain regarding whether cffDNA could trigger a pro-inflammatory response on the pathway to parturition. We hypothesized that placental and/or fetal DNA stimulates toll-like receptor 9
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