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Safety Information

F100

Sigma-Aldrich

Fluspirilene

Synonym(s):

8-[4,4-bis(p-Fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4.5]decan-4-one, R 6218

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10 MG
¥26,500
50 MG
¥89,000

¥26,500

Estimated to ship onAugust 12, 2025From市川市大町368

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10 MG
¥26,500
50 MG
¥89,000

About This Item

Empirical Formula (Hill Notation):
C29H31F2N3O
CAS Number:
1841-19-6
Molecular Weight:
475.57
EC Number:
217-418-6
MDL number:
MFCD00055137
UNSPSC Code:
12352200
PubChem Substance ID:
24277915
NACRES:
NA.77

¥26,500

Estimated to ship onAugust 12, 2025From市川市大町368

New, lower price on this item!
Request a Bulk Order

Assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: ≥20 mg/mL
H2O: insoluble
ethanol: soluble

originator

Johnson & Johnson

storage temp.

room temp

SMILES string

Fc1ccc(cc1)C(CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4)c5ccc(F)cc5

InChI

1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35)

InChI key

QOYHHIBFXOOADH-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

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Application

Fluspirilene has been used as a neuroleptic drug to study its effects on human ether-a-go-go related gene (HERG).[1]
Fluspirilene has been used to study its cytotoxicity effect on malignant glioma.[2]

Biochem/physiol Actions

Fluspirilene has a potential to inhibit the activity of cyclin-dependent kinase 2 (CDK2). It is an effective anti-cancer agent used for treating human hepatocellular carcinoma.[3]
Fluspirilene is a dopamine receptor antagonist.[4] It also acts as a calcium channel blocker.[5] Fluspirilene is an antipsychotic agent and exhibits neuoleptic properties.[5][6] It exhibits therapeutic effects against glioblastoma and Schizophrenia.[6][1]

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

F100-10MG:
F100-BULK:
F100-VAR:
F100-250MG:
F100-50MG:

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Certificates of Analysis (COA)

Lot/Batch Number
0000245411
BGBC3338
103M4604V
060M4615

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Christine Zalejski et al.
Plant physiology, 141(4), 1555-1562 (2006-06-13)
Diacylglycerol pyrophosphate (DGPP) was recently shown to be a possible intermediate in abscisic acid (ABA) signaling. In this study, reverse transcription-PCR of ABA up-regulated genes was used to evaluate the ability of DGPP to trigger gene expression in Arabidopsis (Arabidopsis
Su-Jane Wang
Synapse (New York, N.Y.), 44(1), 36-41 (2002-02-14)
Fluspirilene, a neuroleptic drug which is used clinically to treat schizophrenic patients, is a dopamine D2 receptor antagonist. Besides its well-known actions on the dopamine receptors, fluspirilene also displays calcium channel-blocking activity. The aim of this study was to investigate
Qin Cao et al.
Nature chemistry (2018-10-10)
Inhibiting the interaction between amyloid-β (Aβ) and a neuronal cell surface receptor, LilrB2, has been suggested as a potential route for treating Alzheimer's disease. Supporting this approach, Alzheimer's-like symptoms are reduced in mouse models following genetic depletion of the LilrB2
Identification of antipsychotic drug fluspirilene as a potential anti-glioma stem cell drug
Dong Y, et al.
Oncotarget, 8(67), 111728-111728 (2017)
The pharmacology of fluspirilene (R 6218), a potent, long-acting and injectable neuroleptic drug.
P A Janssen et al.
Arzneimittel-Forschung, 20(11), 1689-1698 (1970-11-01)
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