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F0301

Sigma-Aldrich

Monoclonal Anti-CD56-FITC antibody produced in mouse

clone C5.9, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Monoclonal Anti-CD56, Anti-NKH-1

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About This Item

MDL number:
MFCD02263245
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

200

conjugate

FITC conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

C5.9, monoclonal

form

buffered aqueous solution

mol wt

antigen 150 kDa

species reactivity

human

technique(s)

flow cytometry: suitable

isotype

IgG2bκ

UniProt accession no.

P13591

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... NCAM1(4684)

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General description

Prepared by conjugation of fluorescein isothiocyanate isomer 1 (FITC). This green dye is efficiently excited at 495 nm and emits at 525 nm.

Immunogen

A cloned human NK cell line termed JT3

Application

Monoclonal Anti-CD56-FITC antibody produced in mouse is suitable for fluorescence microscopy. It was also used for flow cytometric analysis.

Biochem/physiol Actions

Neural Cell Adhesion Molecule (NCAM or the cluster of differentiation CD56) is a homophilic binding glycoprotein. It is expressed on the surface of neurons, glia, skeletal muscle and natural killer cells. CD56 can also be expressed in normal immature granulocytes at different expression levels in regenerative bone marrow. It is associated with cardiac genes induced by metabolic stress and its expression is associated with worsening hemodynamic parameters and major metabolic genes. CD56 is involved in left ventricular remodeling and can be implicated in heart failure. It is is developmentally regulated and may have an important role in cardiac development.

Physical form

Solution in phosphate buffered saline, pH 7.4, containing 0.2% gelatin and 0.08% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

F0301-100TST-PW:
F0301-BULK:
F0301-100TST:
F0301-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A A Reyes et al.
Molecular and cellular biology, 11(3), 1654-1661 (1991-03-01)
The major membrane-associated or transmembrane isoforms of the neural cell adhesion molecule (NCAM) are generated by alternative splicing at the 3' end of the mRNA. Further diversity in NCAM structure is observed in the extracellular region of the polypeptide, where
Kazuo Muroi et al.
Journal of clinical and experimental hematopathology : JCEH, 53(3), 247-250 (2013-12-27)
Bone marrow mononuclear cells from 93 patients with hematological malignancies after allogeneic hematopoietic stem cell transplantation (AHSCT) were analyzed using flow cytometry (FCM). The disease was acute myeloblastic leukemia (50 patients), acute lymphoblastic leukemia, and others. Conditioning was myeloablative (80
Takaki Asano et al.
Frontiers in immunology, 9, 568-568 (2018-04-21)
Activated PI3Kδ syndrome (APDS) is a primary immunodeficiency characterized by recurrent respiratory tract infections, lymphoproliferation, and defective IgG production. Heterozygous mutations in PIK3CD, PIK3R1, or PTEN, which are related to the hyperactive phosphoinositide 3-kinase (PI3K) signaling, were recently presented to
Kazuya Nagao et al.
Circulation. Heart failure, 7(2), 351-358 (2013-12-25)
Recently, we screened for cardiac genes induced by metabolic stress and identified neural cell adhesion molecule (NCAM) as a candidate. This study aimed to clarify the expression pattern of NCAM in human cardiomyopathy. A total of 64 cardiac tissue samples
Branka Petricevic et al.
Journal of translational medicine, 11, 307-307 (2013-12-18)
Monoclonal antibodies (mAb), such as trastuzumab are a valuable addition to breast cancer therapy. Data obtained from neoadjuvant settings revealed that antibody-dependent cell-mediated cytotoxicity (ADCC) is a major mechanism of action for the mAb trastuzumab. Conflicting results still call into
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