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Safety Information

E6500

Sigma-Aldrich

Ergonovine maleate salt

Synonym(s):

Ergometrine maleate salt

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About This Item

Empirical Formula (Hill Notation):
C19H23N3O2 · C4H4O4
CAS Number:
129-51-1
Molecular Weight:
441.48
EC Number:
204-953-5
MDL number:
MFCD00672896
UNSPSC Code:
12352200
NACRES:
NA.77

storage temp.

−20°C

SMILES string

OC(=O)\C=C/C(O)=O.C[C@@H](CO)NC(=O)[C@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34

InChI

1S/C19H23N3O2.C4H4O4/c1-11(10-23)21-19(24)13-6-15-14-4-3-5-16-18(14)12(8-20-16)7-17(15)22(2)9-13;5-3(6)1-2-4(7)8/h3-6,8,11,13,17,20,23H,7,9-10H2,1-2H3,(H,21,24);1-2H,(H,5,6)(H,7,8)/b;2-1-/t11-,13+,17+;/m0./s1

InChI key

YREISLCRUMOYAY-IIPCNOPRSA-N

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Biochem/physiol Actions

Oxytocic, potent antagonist at smooth muscle serotonergic receptors.
Oxytocic, stimulates contraction of uterine muscle; partial agonist at serotonergic and dopaminergic receptors in CNS; selective, potent antagonist at smooth muscle serotonergic receptors.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301 + H311 + H331

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

E6500-VAR:
E6500-BULK:
E6500-25MG:
E6500-500MG:
E6500-100MG:

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Certificates of Analysis (COA)

Lot/Batch Number
054H1077
080K0955
068F0320

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Kyeong Ho Yun et al.
International heart journal, 52(6), 338-342 (2011-12-23)
Even patients without vasospastic angina show vasoconstriction after intracoronary ergonovine administration. We evaluated the determinants of coronary artery responsiveness to ergonovine in such patients.In 165 patients with no provoked electrocardiographic changes or ischemic chest pain during an intracoronary ergonovine test
Hosam E Matar et al.
BMC pregnancy and childbirth, 10, 32-32 (2010-06-24)
Care for women during the third stage aims to reduce the risk of major haemorrhage, but is very variable. The current World Health Organisation (WHO) recommendation is that care should include administration of a uterotonic (oxytocin, if it is available)
Kerry E Goetz et al.
Current genetics, 57(3), 201-211 (2011-03-17)
Genes required for ergot alkaloid biosynthesis are clustered in the genomes of several fungi. Several conserved ergot cluster genes have been hypothesized, and in some cases demonstrated, to encode early steps of the pathway shared among fungi that ultimately make
Alsaeed A Askar et al.
Archives of gynecology and obstetrics, 284(6), 1359-1365 (2011-02-22)
To assess and compare the efficacy and safety of a single intramuscular dose of carbetocin to a single intramuscular dose of syntometrine in managing the third stage of labor following vaginal delivery among women with low risk factors for postpartum
Rany Harara et al.
The journal of obstetrics and gynaecology research, 37(9), 1203-1207 (2011-04-27)
The aim of this work was to compare the effect of intraumbilical injection of three different uterotonic solutions in the management of retained placenta. This study was conducted in Ain-Shams University Maternity Hospital, Cairo, Egypt. A total of 78 women
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