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E1518

Sigma-Aldrich

Echistatin from Echis carinatus

lyophilized powder, γ-irradiated, BioXtra

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About This Item

CAS Number:
129038-42-2
MDL number:
MFCD00081572
UNSPSC Code:
12352202
NACRES:
NA.75

biological source

Echis carinatus

Quality Level

200

sterility

γ-irradiated

product line

BioXtra

Assay

>95% (SDS-PAGE)

form

lyophilized powder

mol wt

5.2-5.4 kDa

packaging

pkg of 50 μg

technique(s)

cell culture | mammalian: suitable

solubility

water: soluble 0.1 mg/mL, clear, colorless

shipped in

ambient

storage temp.

−20°C

InChI key

XLBBKEHLEPNMMF-SSUNCQRMSA-N

General description

Echistatin is a small peptide disintegrin that has no multiple epitopes.[1] It is a single chain polypeptide with a molecular mass of 5400. Echistatin has eight cysteines and the sequence arginine glycine aspartic acid (RGD).[2]

Application

Echistatin from Echis carinatus has been used in diabetic rabbits grouping and treatment[3] and murine iPSC (induced pluripotent stem cell) culture.[4]

Biochem/physiol Actions

Disintegrins represent a novel family of integrin β1 and β3 inhibitor proteins isolated from viper venoms. They are low molecular-weight, cysteine-rich peptides containing the Arg-Gly-Asp (RGD) sequence. They are the most potent known inhibitors of integrin function. Disintegrins interfere with cell adhesion to the extracellular matrix, including adhesion of melanoma cells and fibroblasts to fibronectin, and are potent inhibitors of platelet aggregation.
Echistatin has the ability to prevent IRS-1 (insulin receptor substrate-1) phosphorylation induced by IGF-1 (insulin like growth factor-1).[1] Echistatin α1, purified from the venom of the saw scaled viper, Echis carinatus has the capability to block platelet aggregation.[2]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

E1518-50UG-PW:
E1518-VAR:
E1518-BULK:
E1518-50UG:

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Certificates of Analysis (COA)

Lot/Batch Number
11130308
047M4023V
014M4099V
013M4104V
11120133

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Insulin-like Growth Factor Receptor Signalling (2003)
Ozge Er et al.
Applied biochemistry and biotechnology, 187(4), 1539-1550 (2018-10-03)
Snake venoms are a natural biological source that has potential therapeutic value with various protein compounds. Disintegrins originally were discovered as a family of proteins from snake venoms composed of cysteine rich low molecular weight polypeptides. Disintegrins exhibit specific binding
Echistatin prevents posterior capsule opacification in diabetic rabbit model via integrin linked kinase signaling pathway.
Lin F, et al.
International Journal of Clinical and Experimental Pathology, 8(11), 14294-14294 (2015)
Animal Toxins: Facts and Protocols (2013)
Fengbin Lin et al.
International journal of clinical and experimental pathology, 8(11), 14294-14304 (2016-01-30)
To investigate the effect of disintegrin echistatin on integrin linked kinase (ILK) and subsequent PI3-K/Akt and ERK1/2 signaling pathways in the posterior capsule opacification (PCO) model of diabetic rabbit. 56 rabbits were injected alloxan to model diabetic. Then they accepted
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