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E0159

Sigma-Aldrich

Efonidipine hydrochloride monoethanolate

≥98% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C34H38N3O7P · HCl · C2H5OH
CAS Number:
111011-76-8
Molecular Weight:
714.18
MDL number:
MFCD00875717
UNSPSC Code:
12352200
PubChem Substance ID:
329798945
NACRES:
NA.25

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

pale yellow

solubility

DMSO: >5 mg/mL
H2O: insoluble

originator

Shionogi

storage temp.

2-8°C

SMILES string

Cl.CCO.CC1=C(C(c2cccc(c2)[N+]([O-])=O)C(=C(C)N1)P3(=O)OCC(C)(C)CO3)C(=O)OCCN(Cc4ccccc4)c5ccccc5

InChI

1S/C34H38N3O7P.C2H6O.ClH/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45;1-2-3;/h5-17,20,31,35H,18-19,21-23H2,1-4H3;3H,2H2,1H3;1H

InChI key

IKBJGZQVVVXCEQ-UHFFFAOYSA-N

Biochem/physiol Actions

Racemic efonidipine has both L-type and T-type calcium channel blocking activity. The R(−)-isomer appears to be very selective for T-type calcium channel. The S(+)-isomer inhibits the expressed Ca(V)1.2, Ca(V)1.3 and Ca(V)3.1 channel currents almost equally.

Features and Benefits

This compound was developed by Shionogi. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

E0159-BULK:
E0159-25MG:
E0159-VAR:
E0159-5MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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