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D7625

Sigma-Aldrich

2′-Deoxycytidine 5′-monophosphate sodium salt

Sigma Grade, ≥98%

Synonym(s):

Deoxycytidylic acid, dCMP

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100 MG
¥11,500
1 G
¥72,900

About This Item

Linear Formula:
C9H12N3O7PNa2
CAS Number:
13085-50-2
Molecular Weight:
351.16
EC Number:
235-995-2
MDL number:
MFCD00069774
UNSPSC Code:
41106305
PubChem Substance ID:
24894142
NACRES:
NA.51

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biological source

microbial (fermentation)

grade

Sigma Grade

Assay

≥98%

form

powder

storage temp.

−20°C

SMILES string

[Na].NC1=NC(=O)N(C=C1)C2CC(O)C(COP(O)(O)=O)O2

InChI

1S/C9H14N3O7P.Na.H/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17;;/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17);;

InChI key

BLEUYVBRJBDVEH-UHFFFAOYSA-N

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Application

2′-Deoxycytidine 5′-monophosphate sodium salt has been used:
  • in nucleoside stability studies in human renal cell carcinoma (RCC) cell line SN12C[1]
  • in the cell proliferation studies of human intestinal Caco-2 cell line[2] and peripheral blood mononuclear cells (PBMCs)[3]
  • as a ligand in dsDNA activation-induced cytidine deaminase crystallization[4]
2′-Deoxycytidine 5-monophosphate (dCMP) is used as a substrate of uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) to form dCDP which upon phosphorylation to dCTP supports DNA and RNA biosynthesis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

D7625-VAR:
D7625-1G:
D7625-BULK:
D7625-100MG:
D7625-250MG:

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Certificates of Analysis (COA)

Lot/Batch Number
0000382415
0000354134
0000382415
0000354134
0000296784

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AID recognizes structured DNA for class switch recombination
Qiao Q, et al.
Molecular Cell, 67(3), 361-373 (2017)
CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer
Zauri M, et al.
Nature, 524(7563), 114-114 (2015)
Dietary nucleotides and human immune cells. II. Modulation of PBMC growth and cytokine secretion
Holen E, et al.
Nutrition, 22(1), 90-96 (2006)
Rafael Andrade Caceres et al.
Journal of molecular modeling, 14(5), 427-434 (2008-03-18)
Bacterial cytidylate kinase or cytidine monophosphate kinase (CMP kinase) catalyses the phosphoryl transfer from ATP to CMP and dCMP, resulting in the formation nucleoside diphosphates. In eukaryotes, CMP/UMP kinase catalyses the conversion of UMP and CMP to, respectively, UDP and
Dietary nucleotides and intestinal cell lines: I. Modulation of growth
Holen E and Jonsson R
Nutrition Research (New York, N.Y.), 24(3), 197-207 (2004)
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