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D4010

Sigma-Aldrich

2′-Deoxyguanosine 5′-triphosphate sodium salt hydrate

≥96% (HPLC)

Synonym(s):

2′-deoxy-, 5′-triphosphate sodium salt, Guanosine, dGTP sodium salt hydrate

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10 MG
¥38,600
100 MG
¥251,000
1 G
¥1,300,000

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10 MG
¥38,600
100 MG
¥251,000
1 G
¥1,300,000

About This Item

Empirical Formula (Hill Notation):
C10H16N5O13P3 · xNa+ · yH2O
CAS Number:
18423-40-0
Molecular Weight:
507.18 (anhydrous free acid basis)
MDL number:
MFCD01311036
UNSPSC Code:
41106305
PubChem Substance ID:
24893806
NACRES:
NA.51

¥38,600

In StockDetails

New, lower price on this item!

biological source

synthetic (organic)

Assay

≥96% (HPLC)

form

powder

shipped in

dry ice

storage temp.

−20°C

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Application

2′-Deoxyguanosine 5′-triphosphate sodium salt hydrate has been used:
  • as a component in a polymerase chain reaction (PCR) mixture for PCR product formation using AM-toxin primers[1]
  • as an internal standard to improve the analytical performance of capillary electrophoresis (CE) analysis for the evaluation of the cleanup process[2]
  • as a putative substrate in in vitro enzyme activity assay to incubate with nudix hydrolase 15 (NUDT15) protein for the evaluation of putative NUDT15 inhibitors[3]

Biochem/physiol Actions

Deoxyguanosine 5′-triphosphate (dGTP), a purine deoxynucleotide, is a substrate of DNA polymerase(s) and reverse transcriptases. dGTP is useful to study the distribution, specificity, and kinetics of various nucleoside-triphosphatases (NTPase) and ribonucleotide reductases.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

D4010-25MG:
D4010-1G:
D4010-10MG:
D4010-VAR:
D4010-100MG:
D4010-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
0000318160
0000318160
SLCH9981
SLBW7567
SLBH9340V

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Yogesh A Karpe et al.
PloS one, 6(7), e22336-e22336 (2011-08-04)
Chikungunya virus (CHIKV) is an insect borne virus (genus: Alphavirus) which causes acute febrile illness in humans followed by a prolonged arthralgic disease that affects the joints of the extremities. Re-emergence of the virus in the form of outbreaks in
Rajesh Kasiviswanathan et al.
The Journal of biological chemistry, 286(36), 31490-31500 (2011-07-23)
During DNA synthesis, DNA polymerases must select against ribonucleotides, present at much higher levels compared with deoxyribonucleotides. Most DNA polymerases are equipped to exclude ribonucleotides from their active site through a bulky side chain residue that can sterically block the
Inchul Yang et al.
Analytical biochemistry, 335(1), 150-161 (2004-11-03)
A novel approach for quantitation of DNA (oligonucleotides) with an unprecedented accuracy of approximately 1% is reported. Quantitation of DNA is commonly performed by measuring UV absorption or fluorescence from dyes intercalated into DNA. Both methods need accurate quantitation standards
Si Min Zhang et al.
Cell chemical biology, 28(12), 1693-1702 (2021-07-01)
Ganciclovir (GCV) is the first-line therapy against human cytomegalovirus (HCMV), a widespread infection that is particularly dangerous for immunodeficient individuals. Closely resembling deoxyguanosine triphosphate, the tri-phosphorylated metabolite of GCV (GCV-TP) is preferentially incorporated by the viral DNA polymerase, thereby terminating
D O Zharkov et al.
The Journal of biological chemistry, 275(37), 28607-28617 (2000-07-08)
Genomic DNA is prone to oxidation by reactive oxygen species. A major product of DNA oxidation is the miscoding base 8-oxoguanine (8-oxoG). The mutagenic effects of 8-oxoG in mammalian cells are prevented by a DNA repair system consisting of 8-oxoguanine-DNA
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