Skip to Content
Merck
All Photos(1)

Key Documents

Safety Information

D033

Sigma-Aldrich

(+)-Butaclamol hydrochloride

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C25H31NO · HCl
CAS Number:
Molecular Weight:
397.98
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Pricing and availability is not currently available.

form

powder

Quality Level

optical activity

[α]27/D +222° in methanol(lit.)

storage condition

desiccated

color

white

solubility

DMSO: >10 mg/mL, clear

SMILES string

Cl[H].[H][C@@]12C[C@@](O)(CCN1C[C@@]3([H])c4ccccc4CCc5cccc2c35)C(C)(C)C

InChI

1S/C25H31NO.ClH/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25;/h4-10,21-22,27H,11-16H2,1-3H3;1H/t21-,22-,25-;/m0./s1

InChI key

QZRUMKUMFJJARD-AAJWHBHYSA-N

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
HPA019130HPA018133HPA025019
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

UniProt accession no.

Q9Y508

UniProt accession no.

Q9Y4L5

UniProt accession no.

Q8WVD5

UniProt accession no.

Q8NC26

Gene Information

human ... RNF114(55905)

Gene Information

human ... RNF115(27246)

Gene Information

human ... RNF141(50862)

Gene Information

human ... ZNF114(163071)

Application

(+)-Butaclamol hydrochloride has been used as a dopamine receptor blocker in:
  • dissected brain sections[1]
  • striatum of Parkinson′s disease specimens[2]
  • human embryonic kidney cells (HEK293 cells)[3]
  • mice striatal tissue[4]

Biochem/physiol Actions

(+)-Butaclamol is a dopamine receptor antagonist and is an active enantiomer.[5]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

D033-5MG:
D033-BULK:
D033-IP:
D033-500MG:
D033-VAR:
D033-25MG:


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Need A Sample COA?

This is a sample Certificate of Analysis (COA) and may not represent a recently manufactured lot of this specific product.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Shoma Sato et al.
The Journal of physiology, 596(12), 2447-2461 (2018-04-17)
Synaptic potentiation in Drosophila is observed at cholinergic synapses between antennal lobe (AL) and mushroom body (MB) neurons in the adult brain; however, depression at the AL-MB synapses has not yet been identified. By ex vivo Ca2+ imaging in an
Miriam E Bocarsly et al.
Cell reports, 29(5), 1147-1163 (2019-10-31)
Alcohol produces both stimulant and sedative effects in humans and rodents. In humans, alcohol abuse disorder is associated with a higher stimulant and lower sedative responses to alcohol. Here, we show that this association is conserved in mice and demonstrate
P J Pauwels et al.
British journal of pharmacology, 134(1), 88-97 (2001-08-28)
1. Antipsychotic drugs may mediate their therapeutic effects not only by preventing the binding of dopamine but also by decreasing the propensity of the dopamine receptor to assume an active R* state. Ligand-mediated activation and blockade of the recombinant human
Kimberly Regna et al.
BMC developmental biology, 16(1), 15-15 (2016-05-18)
Insect metamorphosis relies on temporal and spatial cues that are precisely controlled. Previous studies in Drosophila have shown that untimely activation of genes that are essential to metamorphosis results in growth defects, developmental delay and death. Multiple factors exist that
Seeman
Pharmacological Reviews, 32, 229-229 (1981)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service