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C8849

Sigma-Aldrich

α-Chloralose−HBC complex

≥92% α-anomer basis

Synonym(s):

1,2-O-(2,2,2-Trichloroethylidene)-α-D-glucofuranose: 2-hydroxypropyl-β-cyclodextrin complex

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥92% α-anomer basis

form

powder

shelf life

4 weeks at 4 °C (for aqueous solutions)

solubility

H2O: freely soluble

Application

α-Chloralose-HBC complex has been used for anesthetizing rats for various in vivo studies.

Biochem/physiol Actions

α-Chloralose-HBC complex is a preferred anesthetic over isoflurane as it displays no intrusion retinal spreading depolarization (rSD) generation and propagation.

Quality

α-Chloralose content: 10% (w/w)

Pictograms

Environment
GHS09

Signal Word

Warning

Hazard Statements

H410

Precautionary Statements

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

C8849-10G:
C8849-IP:
C8849-BULK:
C8849-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Anja I Srienc et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 36(9), 1579-1591 (2016-07-09)
Cortical spreading depolarization is a metabolically costly phenomenon that affects the brain in both health and disease. Following severe stroke, subarachnoid hemorrhage, or traumatic brain injury, cortical spreading depolarization exacerbates tissue damage and enlarges infarct volumes. It is not known
Tess E Kornfield et al.
eNeuro, 2(2) (2015-06-18)
Blood flow is a useful indicator of the metabolic state of the retina. However, accurate measurement of retinal blood flow is difficult to achieve in practice. Most existing optical techniques used for measuring blood flow require complex assumptions and calculations.
Kyle R Biesecker et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(36), 9435-9445 (2016-09-09)
The brain is critically dependent on the regulation of blood flow to nourish active neurons. One widely held hypothesis of blood flow regulation holds that active neurons stimulate Ca(2+) increases in glial cells, triggering glial release of vasodilating agents. This
J Silverman et al.
Laboratory animal science, 43(3), 210-216 (1993-06-01)
Chloral hydrate (CH) and alpha-chloralose (CS) are often used to anesthetize laboratory animals although, to our knowledge, there have been no controlled studies of their anesthetic or analgesic effects. Induction of and recovery from anesthesia can be stressful, and anesthesia
Tess E Kornfield et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(34), 11504-11513 (2014-08-22)
Light stimulation evokes neuronal activity in the retina, resulting in the dilation of retinal blood vessels and increased blood flow. This response, named functional hyperemia, brings oxygen and nutrients to active neurons. However, it remains unclear which vessels mediate functional

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