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Safety Information

C7866

Sigma-Aldrich

CGP-53353

solid

Synonym(s):

5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione, DAPH 2

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About This Item

Empirical Formula (Hill Notation):
C20H13F2N3O2
CAS Number:
145915-60-2
Molecular Weight:
365.33
MDL number:
MFCD00938569
UNSPSC Code:
12352200
PubChem Substance ID:
24892990
NACRES:
NA.77

biological source

synthetic (organic)

Assay

≥98% (HPLC)

form

solid

color

orange

solubility

DMSO: >10 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

Fc1ccc(Nc2cc3C(=O)NC(=O)c3cc2Nc4ccc(F)cc4)cc1

InChI

1S/C20H13F2N3O2/c21-11-1-5-13(6-2-11)23-17-9-15-16(20(27)25-19(15)26)10-18(17)24-14-7-3-12(22)4-8-14/h1-10,23-24H,(H,25,26,27)

InChI key

RONQPWQYDRPRGG-UHFFFAOYSA-N

Gene Information

human ... EGFR(1956)

Biochem/physiol Actions

Selective PKCβII inhibitor. IC50 - 410 nM for PKCβII vs 3.8 μM for PKCβI. Inhibits nPKCs and aPKCs only above 22 μM and other kinases such as protein kinase A, casein kinase I and II, c-src kinase, c-lyn kinase, c-fgr kinase, and v-abl kinase at an IC50 of greater than 50 μM.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

C7866-VAR:
C7866-BULK:
C7866-5MG:
C7866-25MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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