C7861

Citalopram hydrobromide

≥98% (HPLC), powder, serotonin uptake inhibitor

• Synonym(s): 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide
• Empirical Formula (Hill Notation): C₂₀H₂₁FN₂O · HBr
• CAS Number: 59729-32-7
• Molecular Weight: 405.30
• EC Number: 261-890-6
• MDL number: MFCD02101306
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278335
• NACRES: NA.77

Properties

• Product Name: Citalopram hydrobromide, ≥98% (HPLC)
• Assay: ≥98% (HPLC)
• form: powder
• solubility: chloroform: soluble; methanol: soluble
• originator: Forest Labs
• storage temp.: 2-8°C
• SMILES string: Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3
• InChI: 1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H
• InChI key: WIHMBLDNRMIGDW-UHFFFAOYSA-N
• Gene Information: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

Description

General description

Citalopram is a bicyclic phthalene derivative.[1] It initiates serotonergic activity, which produces antidepressant action. Citalopram hydrobromide reverses memory impairment.[2] It is used to treat obsessive compulsive disorder,[1] panic disorder, sociophobia and premenstrual dysphoric disorder.[3]

Application

Citalopram hydrobromide has been used:

• to examine its effects on sirt mRNA and mammalian sirtuins (SIRT) expression in mice[4]
• to monitor body temperature and antidepressant-like behavioral responses in the forced swim test for rats[5][6]
• for 5-hydroxytryptamine (5-HT) competition uptake assays[7]

Biochem/physiol Actions

Potent and selective serotonin uptake inhibitor (K_i = 5.4 nM); antidepressant

Features and Benefits

This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Warning
• Hazard Statements: H302,H336,H361d,H412
• Precautionary Statements: P202 - P261 - P264 - P273 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3
• Target Organs: Central nervous system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves