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Safety Information

C6108

Sigma-Aldrich

Calpain 1 human

aqueous glycerol solution

Synonym(s):

Calcium-activated neutral protease 1

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About This Item

Enzyme Commission number:
3.4.22.52 (BRENDA, IUBMB)
MDL number:
MFCD00217575
UNSPSC Code:
12352204
NACRES:
NA.54

Assay

≥95% (SDS-PAGE)

form

aqueous glycerol solution

specific activity

≥1000 U/mg

UniProt accession no.

P07384

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CAPN1(823)

Application

Human calpain 1 has been used in a study to assess how the crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. Human calpain 1 has also been used in a study to investigate the synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors.

Biochem/physiol Actions

Caplain 1 is a neutral calcium-dependent cysteine protease containing the EF-hand motif. The protease consists of two subunits; the larger subunit has four domains that are homologous with papain and calmodulin. The smaller subunit has one domain that shares homology with calmodulin. It is activated by micromolar levels of calcium and hence, it is also called as micro-calpain. Its activation leads to cellular protein degradation, neuronal cell degeneration, and autoimmune demyelinating diseases such as multiple sclerosis.
Cytosolic protease with involvement in cytoskeletal remodeling, autophagy, and apoptosis as an upstream regulator.

Physical properties

Calpain 1 is a heterodimeric calcium-activated thiol-protease.

Unit Definition

One unit will hydrolyze 1 picomole Suc-LLVY-AMC per minute at 25 deg C.

Physical form

Solution in 20 mM Imidazole-HCl, 5 mM β-Mercaptoethanol, 1 mM EDTA, 1 mM EGTA, and 30% glycerol.

inhibitor

Product No.
Description
Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

C6108-VAR:
C6108-100UG-PW:
C6108-100UG:
C6108-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
SLCN7423
SLBR9406V
SLCL3627
SLCK6427
SLCJ3343

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Tarun Tyagi et al.
Blood, 123(8), 1250-1260 (2013-12-04)
Oxygen-compromised environments, such as high altitude, air travel, and sports, and pathological conditions, such as solid tumors, have been suggested to be prothrombotic. Despite the indispensable role of platelets in thrombus formation, the studies linking hypoxia, platelet reactivity, and thrombus
Nicholas B Woodall et al.
Nature structural & molecular biology, 28(9), 762-770 (2021-09-15)
Kinases play central roles in signaling cascades, relaying information from the outside to the inside of mammalian cells. De novo designed protein switches capable of interfacing with tyrosine kinase signaling pathways would open new avenues for controlling cellular behavior, but
M K Squier et al.
Journal of immunology (Baltimore, Md. : 1950), 158(8), 3690-3697 (1997-04-15)
Apoptosis is the common phenotype of programmed or physiologic cell death, the process used to remove excess or defunct cells during normal tissue maintenance. One of the most studied cell types with respect to apoptosis is the immature T cell
Xuan Zhang et al.
PloS one, 7(2), e31458-e31458 (2012-02-23)
Hepatitis B virus X protein (HBx) plays an important role in the development of hepatocellular carcinoma (HCC). However, the mechanism remains unclear. Recently, we have reported that HBx promotes hepatoma cell migration through the upregulation of calpain small subunit 1
Rebecca M Kandell et al.
ACS nano, 15(12), 20504-20516 (2021-12-07)
Traumatic brain injury (TBI) is a critical public health concern and major contributor to death and long-term disability. After the initial trauma, a sustained secondary injury involving a complex continuum of pathophysiology unfolds, ultimately leading to the destruction of nervous
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