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Safety Information

B8279

Sigma-Aldrich

Ro-20-1724

≥98% (HPLC), solid, cAMP phosphodiesterase inhibitor

Synonym(s):

Ro 20-1724

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About This Item

Empirical Formula (Hill Notation):
C15H22N2O3
CAS Number:
29925-17-5
Molecular Weight:
278.35
MDL number:
MFCD00077397
UNSPSC Code:
41106305
PubChem Substance ID:
24278195
NACRES:
NA.77

product name

4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one, solid

biological source

synthetic (organic)

Quality Level

200

Assay

≥98% (HPLC)

form

solid

solubility

ethanol: 7 mg/mL
H2O: insoluble

storage temp.

room temp

SMILES string

CCCCOc1cc(CC2CNC(=O)N2)ccc1OC

InChI

1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)

InChI key

PDMUULPVBYQBBK-UHFFFAOYSA-N

Gene Information

human ... LITAF(9516) , PDE4B(5142) , PRKAR1A(5573) , PRKAR1AP(5574) , PRKAR1B(5575) , PRKAR2A(5576) , PRKAR2B(5577)
rat ... Pde4a(25638)

Application

4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one has been used:
  • as a cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitor to treat cells for the determination of intracellular cAMP levels
  • as a component of serum-free medium
  • as phosphodiesterase inhibitor in order to study the effects of protease-activated receptor-1 (PAR-1) activation on cAMP levels

Biochem/physiol Actions

Inhibitor of cAMP phosphodiesterase. IC50 33 μM in vascular smooth muscle of the aorta.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

B8279-500MG:
B8279-VAR:
B8279-BULK:
B8279-100MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Abscisic acid (ABA) is a phytohormone regulating important functions in higher plants, notably responses to abiotic stress. Recently, chemical or physical stimulation of human granulocytes was shown to induce production and release of endogenous ABA, which activates specific cell functions.
Regulation of sleep by the short neuropeptide F (sNPF) in Drosophila melanogaster
Chen W, et al.
Insect Biochemistry and Molecular Biology, 43(9), 809-819 (2013)
Abscisic acid activates the murine microglial cell line N9 through the second messenger cyclic ADP-ribose
Bodrato N, et al.
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Farhan A Khawaja et al.
Hippocampus, 17(12), 1143-1148 (2007-09-21)
The entorhinal cortex (EC), located in the medial temporal lobe (MTL) of the brain, plays an important functional role in the MTL memory circuit. Medial EC (MEC) Layer II stellate cells (SCs) serve as one of the most prominent target
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