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B7260

Sigma-Aldrich

Nα-Benzoyl-L-arginine-7-amido-4-methylcoumarin hydrochloride

protease substrate, ≥99% (TLC), powder

Synonym(s):

Bz-Arg-AMC hydrochloride

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5 MG
¥29,600
25 MG
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About This Item

Empirical Formula (Hill Notation):
C23H25N5O4 · HCl
CAS Number:
83701-04-6
Molecular Weight:
471.94
MDL number:
MFCD00039020
UNSPSC Code:
12352204
PubChem Substance ID:
24891979
NACRES:
NA.83

¥29,600

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Product Name

Nα-Benzoyl-L-arginine-7-amido-4-methylcoumarin hydrochloride, protease substrate

Assay

≥99% (TLC)

form

powder

solubility

DMSO:methanol (1:1): 20 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

Cl.CC1=CC(=O)Oc2cc(NC(=O)[C@H](CCCNC(N)=N)NC(=O)c3ccccc3)ccc12

InChI

1S/C23H25N5O4.ClH/c1-14-12-20(29)32-19-13-16(9-10-17(14)19)27-22(31)18(8-5-11-26-23(24)25)28-21(30)15-6-3-2-4-7-15;/h2-4,6-7,9-10,12-13,18H,5,8,11H2,1H3,(H,27,31)(H,28,30)(H4,24,25,26);1H/t18-;/m0./s1

InChI key

XKAVYOJOHZLTDF-FERBBOLQSA-N

Application

Nα-Benzoyl-L-arginine-7-amido-4-methylcoumarin hydrochloride has been used:
  • as a substrate for trypsin-like proteolysis of peptide in red blood cells[1]
  • as a substrate for midgut proteases of Pieris brassicae[2]
  • as a substrate in screening serine protease activity of venom[3]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Substrates

A sensitive fluorogenic substrate for papain and trypsin.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

B7260-1MG:
B7260-5MG:
B7260-25MG:
B7260-BULK:
B7260-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ5437
BCCF4906
BCBP5436V
BCBG5111V
BCBD2059V

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Purification and functional characterisation of rhinocerase, a novel serine protease from the venom of Bitis gabonica rhinoceros
Vaiyapuri S, et al.
Testing, 5(3), e9687-e9687 (2010)
Trypsin-like proteolytic contamination of commercially available psa purified from human seminal fluid
Manning ML, et al.
Prostate, 72(11), 1233-1238 (2012)
Kanaoka, Y., et al.
Chemical & Pharmaceutical Bulletin, 25, 3126-3126 (1977)
Rakesh Kumar et al.
Frontiers in physiology, 6, 95-95 (2015-04-16)
Pieris brassicae L. is a serious pest of cultivated crucifers in several parts of the world. Larvae of P. brassicae also feed prolifically on garden nasturtium (Tropaeolum majus L., of the family Tropaeolaceae). Proteolytic digestion was studied in larvae feeding
Daniil N Olennikov et al.
Plants (Basel, Switzerland), 10(11) (2021-11-28)
Prickly rose (Rosaacicularis Lindl.) is the most distributed rose species in the Northern Hemisphere, used by indigenous people for various food purposes. The lack of detailed information about the chemical composition of R. acicularis has led us to study the
View All Related Papers

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