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B4559

Sigma-Aldrich

BRL 44408 maleate salt

≥98% (HPLC)

Synonym(s):

2-[2H-(1-Methyl-1,3-dihydroisoindole)methyl]-4,5-dihydroimidazole maleate salt

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About This Item

Empirical Formula (Hill Notation):
C17H21N3O4
CAS Number:
118343-19-4
Molecular Weight:
331.37
MDL number:
MFCD02262218
UNSPSC Code:
12352200
PubChem Substance ID:
329773239
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: soluble 15 mg/mL, clear

originator

GlaxoSmithKline

SMILES string

OC(=O)\C=C/C(O)=O.CC1N(CC2=NCCN2)Cc3ccccc13

InChI

1S/C13H17N3.C4H4O4/c1-10-12-5-3-2-4-11(12)8-16(10)9-13-14-6-7-15-13;5-3(6)1-2-4(7)8/h2-5,10H,6-9H2,1H3,(H,14,15);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

DDIQGSUEJOOQQQ-BTJKTKAUSA-N

Biochem/physiol Actions

BRL 44408 maleate is a selective α2A-adrenoceptor antagonist.

Features and Benefits

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold under agreement from Glaxo­Smith­Kline

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

B4559-VAR:
B4559-IP:
B4559-50MG:
B4559-BULK:
B4559-10MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Neurochemistry international, 51(5), 297-305 (2007-08-01)
The inhibitory effect of clonidine (non-selective alpha2-adrenoceptor agonist) and oxymetazoline (alpha2A-adrenoceptor selective agonist) was compared on basal and stimulated gastric motor activity (gastric tone and contractions) using the balloon method in the rat. It was shown that oxymetazoline (0.2-1.7 micromol/kg
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Neuroreport, 17(12), 1313-1317 (2006-09-05)
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α2-Adrenoceptors

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