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Safety Information

B109

Sigma-Aldrich

nor-Binaltorphimine dihydrochloride

solid

Synonym(s):

nor-BNI dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C40H43N3O6 · 2HCl
CAS Number:
113158-34-2
Molecular Weight:
734.71
MDL number:
MFCD00069374
UNSPSC Code:
12352103
PubChem Substance ID:
329773161

form

solid

color

tan

solubility

artificial CSF: 2 mg/mL (prepare with sonication for 4 minutes)
H2O: 6.0 mg/mL (aqueous solutions are highly unstable and should be freshly prepared.)
ethanol: soluble

SMILES string

Cl[H].Cl[H].Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6[nH]c7[C@@H]8Oc9c(O)ccc%10C[C@H]%11N(CC[C@@]8(c9%10)[C@@]%11(O)Cc7c6C[C@@]35O)CC%12CC%12)CC%13CC%13

InChI

1S/C40H43N3O6.2ClH/c44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(24)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19;;/h5-8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2;2*1H/t27-,28-,35+,36+,37+,38+,39-,40-;;/m1../s1

InChI key

JOJPJLHRMGPDPV-LZQROVCBSA-N

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Biochem/physiol Actions

Highly selective κ-opioid receptor antagonist.

replaced by

Product No.
Description
Pricing

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

B109-150MG:
B109-200UG:
B109-40MG:
B109-2MG:
B109-500UG:
B109-1MG:
B109-BULK:
B109-250UG:
B109-10MG:
B109-100MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M Dimitrijević et al.
Immunopharmacology, 49(3), 255-262 (2000-09-21)
We have previously demonstrated that central application of leucine-enkephalin (Leu-Enk) elicits potentiation and suppression of humoral immune responses through OP(1) (delta) and OP(2) (kappa) receptors, respectively. Interestingly, both effects were found to be additionally dependent on OP(3) (mu) receptor function.
S A Hjorth et al.
Molecular pharmacology, 47(6), 1089-1094 (1995-06-01)
The structural determinants for the selective binding of the nonpeptide opioid receptor antagonist nor-binaltorphimine (nor-BNI) to the kappa-opioid receptor were characterized using a systematic series of chimeras between the kappa receptor and the homologous mu-opioid receptor. All 10 chimeric constructs
M C Ko et al.
The Journal of pharmacology and experimental therapeutics, 291(3), 1113-1120 (1999-11-24)
Systemic administration of nor-binaltorphimine (nor-BNI) produces a long-lasting kappa-opioid receptor (kappaOR) antagonism and has kappa(1)-selectivity in nonhuman primates. The aim of this study was to establish the pharmacological basis of central kappaOR antagonism in rhesus monkeys (Macaca mulatta). After intracisternal
A E Takemori et al.
The Journal of pharmacology and experimental therapeutics, 246(1), 255-258 (1988-07-01)
Previously, we reported on an opioid antagonist, nor-binaltorphimine (nor-BNI), that had high selectivity for kappa opioid receptors in smooth muscle preparations. In this study, nor-BNI administered either s.c. or i.c.v. was shown to antagonize significantly the antinociceptive effects of the
Juliana Almeida da Silva et al.
European journal of pharmacology, 698(1-3), 235-245 (2013-02-12)
The chemical neuroanatomy and the effects of central administration of opioid antagonists on the innate fear-induced responses elicited by electrical (at escape behaviour threshold) stimulation of the midbrain tectum were determined. The aim of the present work was to investigate
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