Claudin-4 is one of twenty-seven integral membrane tight junction proteins and specializes in paracellular sodium transport. Although claudin proteins are primarily known for their cell adhesion function, Claudin-4 binds to zonula occludens proteins and interacts with numerous signaling pathways. Claudin-4 is detectable in low amounts in the normal tissues of the lung, kidney, breast, prostate, bladder and gastrointestinal tract. It is a highly specific and sensitive membranous marker for most epithelial neoplasms. Absence of expression in normal mesothelium and mesothelioma provides utility in the differential diagnosis between carcinoma from mesothelioma with 99% specificity. In breast tumors, claudin-4 levels are significantly higher in ER-negative and high grade tumors when compared to ER-positive and low grade tumors. High levels of Claudin-4 expression are associated with later stages of progression and reduced patient survival for most types of epithelial neoplasms. Conversely, its expression is downregulated in gastric and high-grade bladder cancers, and is significantly lower in lymph node metastasis and esophageal tumors with distant metastasis. Low Claudin-4 expression is associated with a poor prognosis in esophageal squamous cell carcinoma.
Quality
IVD
IVD
IVD
RUO
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and &< 0.1% Sodium Azide
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
JAN Code
AC-0352:
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