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A8754

Sigma-Aldrich

Methyl α-aminoisobutyrate hydrochloride

Synonym(s):

α-Aminoisobutyric acid methyl ester hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C5H11NO2 · HCl
CAS Number:
15028-41-8
Molecular Weight:
153.61
MDL number:
MFCD00214247
UNSPSC Code:
12352200
PubChem Substance ID:
24891362

Assay

≥98% (TLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white

storage temp.

−20°C

SMILES string

Cl.COC(=O)C(C)(C)N

InChI

1S/C5H11NO2.ClH/c1-5(2,6)4(7)8-3;/h6H2,1-3H3;1H

InChI key

NVWZNEDLYYLQJC-UHFFFAOYSA-N

Biochem/physiol Actions

Methyl α-aminoisobutyrate is used as a specific substrate of amino acid transport system A in studies on amino acid transport systems.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

A8754-500MG:
A8754-5G:
A8754-BULK:
A8754-VAR:
A8754-1G:

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Certificates of Analysis (COA)

Lot/Batch Number
021M5010V
021M5010
028K5103
066K5006
025K5002

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Oak Z Chi et al.
Neurochemical research, 34(7), 1249-1254 (2009-01-08)
This study was performed to determine whether exogenous N-methyl-D: -aspartate (NMDA) or alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) would aggravate blood-brain barrier (BBB) disruption in focal cerebral ischemia in rats. Forty-five minutes after middle cerebral artery (MCA) occlusion, one of the following
A Gadea et al.
Glia, 26(4), 273-279 (1999-06-26)
Rapid termination of the synaptic action of glutamate (Glu) and glycine (Gly) is achieved by uptake into the presynaptic terminal and glial cells. In the vertebrate CNS, Gly acts both as an inhibitory neurotransmitter and as a Glu modulator or
J W Tsang et al.
Journal of medicinal chemistry, 27(12), 1663-1668 (1984-12-01)
Stereochemical and structural aspects of the variations in the C-terminal residue of L-aspartyl-L-phenylalanine methyl ester have been investigated. Novel configurational analogues such as L-aspartyl-D-alanine benzyl ester and L-aspartyl-D-alpha-aminobutyric acid benzyl ester were found to be sweet. In addition, chiral and
Koichi Kato et al.
Bioorganic & medicinal chemistry letters, 21(8), 2437-2440 (2011-03-12)
We describe the synthesis of (11)C-labeled α-aminoisobutyric acid 2 from iodo[(11)C]methane and methyl N-(diphenylmethylen)-d,l-alaniate (5). The tetrabutylammonium fluoride (TBAF)-promoted α-[(11)C]methylation of sterically hindered analog 5 was a key step in our synthesis process. Total radiochemical conversion of 2 was high

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