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A8291

Sigma-Aldrich

L-Aspartic acid β-methyl ester hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C5H9NO4 · HCl
CAS Number:
16856-13-6
Molecular Weight:
183.59
EC Number:
240-880-5
MDL number:
MFCD00038972
UNSPSC Code:
12352200
PubChem Substance ID:
24891327
NACRES:
NA.26

Assay

≥98%

form

powder

color

white

storage temp.

−20°C

SMILES string

Cl.COC(=O)C[C@H](N)C(O)=O

InChI

1S/C5H9NO4.ClH/c1-10-4(7)2-3(6)5(8)9;/h3H,2,6H2,1H3,(H,8,9);1H/t3-;/m0./s1

InChI key

QRBMPUYOGOCYDJ-DFWYDOINSA-N

Biochem/physiol Actions

L-Aspartic acid β-methyl ester is used for the organic synthesis of S-enantiomers of hanishin, longamide B, and longamide B methylester, of 1-β-methylcarbapenem, TA-949 and for the enzymatic synthesis of a CCK-4 tripeptide fragment

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

A8291-VAR:
A8291-5G:
A8291-BULK:
A8291-25G:
A8291-1G:

Certificates of Analysis (COA)

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Jignesh Patel et al.
The Journal of organic chemistry, 70(22), 9081-9084 (2005-10-22)
[reaction: see text] Total syntheses of enantiopure hanishin, longamide B, and longamide B methyl ester are described. Absolute configurations of these natural products have been established.
Li Guo et al.
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA, 23(4), 289-292 (2003-04-17)
To synthesize a tripeptide derivative Phac-Met-Asp(OMe)-Phe -NH2, which is a fragment of the gastrin C-terminal tetrapeptide CCK-4, by enzymatic reaction. Three free enzymes, alpha-chymotrypsin, papain and thermolysin from acyl donor Phac-Met-OCam was involved in three steps. The choice of appropriate
M Seki et al.
The Journal of organic chemistry, 65(2), 517-522 (2000-05-18)
A facile and economical synthesis of a novel orally active 1-beta-methylcarbapenem, TA-949 (1), is described. The key process involves an efficient synthesis of the C-2 side chain (R)-4-mercaptopyrrolidine-2-thione 2 from L-aspartic acid and the construction of the 1-beta-methylcarbapenem skeleton. The

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