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Safety Information

A8026

Sigma-Aldrich

[Sar1, Ala8]-Angiotensin II

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C43H67N13O10
CAS Number:
53935-10-7
Molecular Weight:
926.07
MDL number:
MFCD00167502
UNSPSC Code:
12352200

Assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](C)C(O)=O

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Amino Acid Sequence

Sar-Arg-Val-Tyr-Ile-His-Pro-Ala

Biochem/physiol Actions

Angiotensin II antagonist at1 and AT2 receptors.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

A8026-VAR:
A8026-BULK:
A8026-10MG:
A8026-1MG:
A8026-25MG:
A8026-5MG:

Certificates of Analysis (COA)

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K Kawano et al.
European journal of pharmacology, 357(1), 33-39 (1998-10-27)
Oral administration of the angiotensin AT1 receptor antagonist 3-methyl-2,6-dimethyl-4-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl ]methoxy] pyridine (ME3221) inhibited the pressor response to angiotensin II at doses of 0.3-1.0 mg/kg in rats. A higher dose of ME3221 (3-10 mg/kg) was required to obtain the same inhibitory
C Caruso-Neves et al.
Biochimica et biophysica acta, 1467(1), 189-197 (2000-08-10)
Angiotensin-(1-7) (Ang-(1-7)) modulates the Na+-ATPase, but not the Na+,K+-ATPase activity present in pig kidney proximal tubules. The Na+-ATPase, insensitive to ouabain, but sensitive to furosemide, is stimulated by Ang-(1-7) (68% by 10(-9) M), in a dose-dependent manner. This effect is
European Journal of Pharmacology, 357, 825-825 (1976)

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