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Safety Information

A6351

Sigma-Aldrich

A-315456

>98% (HPLC), solid

Synonym(s):

N-[3-(cyclohexylidene(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C18H23N3O2S
Molecular Weight:
345.46
MDL number:
MFCD04040120
UNSPSC Code:
12352200
PubChem Substance ID:
24278798

Assay

>98% (HPLC)

form

solid

color

off-white

solubility

DMSO: soluble 24 mg/mL
H2O: insoluble

SMILES string

CCS(=O)(=O)Nc1cccc(c1)C(=C2/CCCCC2)\c3cnc[nH]3

InChI

1S/C18H23N3O2S/c1-2-24(22,23)21-16-10-6-9-15(11-16)18(17-12-19-13-20-17)14-7-4-3-5-8-14/h6,9-13,21H,2-5,7-8H2,1H3,(H,19,20)

InChI key

MTZVJHSZYMWIAG-UHFFFAOYSA-N

Gene Information

human ... ADRA1D(146)

Application

A-315456 is a potent and selective α1D-antagonist that may serve as a useful pharmacological ligand to probe the physiological role of the α(1D)-adrenoceptor subtype in normal and disease states.

Biochem/physiol Actions

Selective α1D-adrenoceptor antagonist.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

A6351-5MG:
A6351-25MG:
A6351-VAR:
A6351-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S A Buckner et al.
European journal of pharmacology, 433(1), 123-127 (2002-01-05)
In functional assays, A-315456, N-[3-(cyclohexylidene-(1H-imidazol-4-ylmethyl))phenyl]ethanesulfonamide, behaved as an alpha(1D)-adrenoceptor subtype selective antagonist (pA(2)=8.34) in the rat aorta. It was 83-fold less potent at the alpha(1B)-adrenoceptor subtype expressed in the rat spleen, and was inactive at the alpha(1A)-adrenoceptor subtype expressed in

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