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A4727

Sigma-Aldrich

Antisauvagine-30 trifluoroacetate salt

Synonym(s):

Anti-SVG-30, [D-Phe11,His12]-Sauvagine fragment 11-40 trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):
C161H274N48O46S
Molecular Weight:
3650.26
MDL number:
MFCD04974485
UNSPSC Code:
12352200
NACRES:
NA.32

form

powder

Quality Level

200

storage temp.

−20°C

Gene Information

human ... CRHR2(1395)
mouse ... CRHR2(12922)
rat ... CRHR2(64680)

Amino Acid Sequence

Phe-His-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2

Biochem/physiol Actions

High-affinity antagonist for Corticotropin-releasing factor (CRF) receptor type 2 (CRF(2)).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

A4727-VAR:
A4727-1MG-PW:
A4727-1MG:
A4727-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nina C Donner et al.
Psychoneuroendocrinology, 63, 178-190 (2015-10-12)
Anxiety and affective disorders are often associated with hypercortisolism and dysfunctional serotonergic systems, including increased expression of TPH2, the gene encoding the rate-limiting enzyme of neuronal serotonin synthesis. We previously reported that chronic glucocorticoid exposure is anxiogenic and increases rat

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