A4316
Anantin from Streptomyces coerulescens
≥90% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C90H111N21O24
CAS Number:
Molecular Weight:
1870.97
MDL number:
UNSPSC Code:
12352200
Assay
≥90% (HPLC)
storage temp.
−20°C
Amino Acid Sequence
Cyclo(Gly-Phe-Ile-Gly-Trp-Gly-Asn-β-Asp)-Ile-Phe-Gly-His-Tyr-Ser-Gly-Asp-Phe
Biochem/physiol Actions
Competitive antagonist at atrial natriuretic peptide NPR-A receptors.
Other Notes
A cyclic peptide
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
JAN Code
A4316-BULK:
A4316-VAR:
A4316-250UG:
A4316-1MG:
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D F Wyss et al.
The Journal of antibiotics, 44(2), 172-180 (1991-02-01)
Anantin, a naturally occurring peptide from Streptomyces coerulescens, binds competitively to the receptor of atrial natriuretic factor (ANF) from bovine adrenal cortex (Kd = 0.6 microM) and acts as ANF antagonist. Protein chemical data and FAB-MS have identified anantin to
Sandra L Hrometz et al.
Toxicology letters, 206(2), 234-237 (2011-08-11)
MDMA (3,4-methylenedioxymethamphetamine) induces thermogenesis in a mitochondrial uncoupling protein 3-dependent manner. There is evidence that this hyperthermia is mediated in part by the lipolytic release of free fatty acids, that subsequently activate uncoupling protein 3 in skeletal muscle mitochondria. We
Rouwayda El-Ayoubi et al.
British journal of pharmacology, 145(1), 50-56 (2005-02-09)
We have previously shown that acute intravenous injections of moxonidine and clonidine increase plasma atrial natriuretic peptide (ANP), a vasodilator, diuretic and natriuretic hormone. We hypothesized that moxonidine stimulates the release of ANP, which would act on its renal receptors
J A Carvajal et al.
The Journal of pharmacology and experimental therapeutics, 297(1), 181-188 (2001-03-22)
We tested both relaxation and cGMP generation by atrial (ANP), brain (BNP), and C-type natriuretic peptide (CNP) in oxytocin-stimulated myometrium from near-term pregnant guinea pigs to investigate the ability and mechanism of natriuretic peptides to inhibit myometrial contractility. Myometrial strips
N Ali et al.
Cellular signalling, 12(7), 491-498 (2000-09-16)
We investigated the effects of adrenomedullin (ADM) on cGMP production in cultured SV-40 transformed cat iris sphincter smooth muscle (SV-CISM-2) cells. ADM increased cGMP accumulation in a time- and concentration- dependent manner. The peptide increased cGMP formation in the transformed
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