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Safety Information

A3612

Sigma-Aldrich

Ceftizoxime sodium salt

Synonym(s):

Ceftizoxime sodium

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About This Item

Linear Formula:
C13H12N5NaO5S2
CAS Number:
68401-82-1
Molecular Weight:
405.38
UNSPSC Code:
51284149
NACRES:
NA.85

Assay

≥98% (HPLC)

form

solid

color

white to faint yellow

solubility

DMSO: 1 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

Mode of action

cell wall synthesis | interferes

storage temp.

−20°C

InChI

1S/C13H13N5O5S2.Na/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18;/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22);/q;+1/p-1/b17-7-;/t8-,11-;/m1./s1

InChI key

ADLFUPFRVXCDMO-LIGXYSTNSA-M

Biochem/physiol Actions

Ceftizoxime is third generation cephalosporin effective against Gram-negative and Gram-positive bacteria. It binds penicillin-binding proteins (PBPs) and inhibits the bacterial cell wall synthesis.[1]

Packaging

50mg

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

A3612-BULK:
A3612-50MG:
A3612-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
072M4138V
14120705
108M4838V

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Soraya Maria Zandim Maciel Dias Ferreira et al.
Bioorganic & medicinal chemistry letters, 22(14), 4605-4608 (2012-06-26)
Osteomyelitis is an infectious disease located in the bone or bone marrow. Long-circulating and pH-sensitive liposomes containing a technetium-99m-labeled antibiotic, ceftizoxime, (SpHL-(99m)Tc-CF) were developed to identify osteomyelitis foci. Biodistribution studies and scintigraphic images of bone infection or non infection-bearing rats
Bashier Osman et al.
BMC research notes, 6, 57-57 (2013-02-12)
A prophylactic antibiotic is recommended to reduce infection-related complication following cesarean delivery. There is a current debate on the time of prophylactic antibiotic in cesarean delivery. An opened randomized, controlled clinical trial was conducted at Soba hospital, Sudan to investigate
M Jayahar Bharathi et al.
Ophthalmic research, 47(1), 52-56 (2011-07-02)
To evaluate resistances mediated by extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases among Gram-negative bacteria recovered from ocular infections. As per the Clinical Laboratory Standards Institute M100-S-16 document, a total of 135 Gram-negative bacilli were recovered from ocular specimens and were
Peymaneh Alizadeh Taheri et al.
Acta medica Iranica, 49(8), 499-503 (2011-10-20)
Neonatal sepsis, a life-threatening condition, presents with non-specific clinical manifestations and needs immediate empirical antimicrobial therapy. Choosing an appropriate antibiotic regimen covering the most probable pathogens is an important issue. In this study we compared the effectiveness of ceftizoxime and
Thomas M Hooton et al.
JAMA, 307(6), 583-589 (2012-02-10)
Although fluoroquinolones remain the most reliable urinary antimicrobial, resistance rates have increased and effective fluoroquinolone-sparing antimicrobials are needed. To determine whether cefpodoxime is noninferior to ciprofloxacin for treatment of acute cystitis. Randomized, double-blind trial of 300 women aged 18 to
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