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Safety Information

A2512

Sigma-Aldrich

Albumin from chicken egg white

lyophilized powder, ≥98% (agarose gel electrophoresis)

Synonym(s):

Albumin from hen egg white, Ovalbumin

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About This Item

CAS Number:
EC Number:
MDL number:
UNSPSC Code:
12352202
eCl@ss:
42010201
NACRES:
NA.61

biological source

chicken egg white

type

Grade VI

Assay

≥98% (agarose gel electrophoresis)

form

lyophilized powder

mol wt

44287 Da by calculation

purified by

chromatography

extent of labeling

4-20 mol mannose per mol ovalbumin protein

technique(s)

bioconjugation: suitable

solubility

H2O: soluble 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

UniProt accession no.

storage temp.

2-8°C

Gene Information

chicken ... OVAL(396058)

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General description

Chicken egg albumin is the major protein constituent of egg whites. Chicken egg albumin is a phosphorylated-glycoprotein. From the amino acid sequence, the peptide portion of the molecule consists of 385 residues and has a molecular weight of 42.7 kDa.
Ovalbumin makes 75% of the total egg white protein.

Application

Ovalbumin has been used:
  • as a medium for cell incubation in EliCell assay for the detection of released cytokines from eosinophil
  • to induce allergic inflammation and atopic dermatitis in experimental mice
  • as a component in control mixture for validating tandem mass spectral analysis
  • as a model protein antigen to evaluate the in vivo efficacy of a chitosan/interleukin (IL)-12 adjuvant system
A phosphorylated glycoprotein which is useful as a marker (~45 kDa) for protein electrophoresis. Has been used to produce an animal model of asthma.

Biochem/physiol Actions

Albumin from chicken egg white serves as a natural adhesive.
Differential scanning calorimetry indicates that chicken egg albumin denatures at 84 °C. Ovalbumin can be used as a carrier protein to conjugate to synthetic peptides for use as an immunogen. It has the following amino acids: 20 Lys, 10 Tyr, 6 Cys, 14 Asp, and 33 Glu which make it suitable for conjugation.

Physical form

Essentially salt free

Preparation Note

A further purification of A 5503 to reduce mannose content.

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Resp. Sens. 1A

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

A2512-5G:
A2512-VAR:
A2512-250MG:
A2512-1G:
A2512-BULK:


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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<BIG>Mielenz JR, et al.</BIG>
Biotechnology for Fuels and Chemicals: The Twenty-Eighth Symposium.c, 928-928 (2019)
PTP1B deficiency exacerbates inflammation and accelerates leukocyte trafficking in vivo
<BIG>Berdnikovs S, et al.</BIG>
Journal of Immunology, 188, 874-884 (2012)
<BIG>Unger A, et al.</BIG>
Conservation of Wood Artifacts: A Handbook, 554-554 (2013)
In vivo efficacy of a chitosan/IL-12 adjuvant system for protein-based vaccines
<BIG>Heffernan MJ, et al.</BIG>
Biomaterials, 32, 926-932 (2011)
Experimental protein mixture for validating tandem mass spectral analysis
<BIG>Keller A, et al.</BIG>
Omics : A Journal of Integrative Biology, 6, 207-212 (2002)

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