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Safety Information

A1612

Sigma-Aldrich

AF-353 hydrochloride

≥98% (HPLC), powder

Synonym(s):

5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine hydrochloride, Ro 4 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C14H17IN4O2 · HCl
CAS Number:
927887-18-1
Molecular Weight:
436.68
UNSPSC Code:
12352203

Assay

≥98% (HPLC)

form

powder

color

off-white to light brown

solubility

DMSO: >10 mg/mL

originator

Roche

storage temp.

2-8°C

SMILES string

Cl.COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1I

Biochem/physiol Actions

AF-353 is a P2X3, P2X2/3 antagonist.
AF-353 is a potent antagonist of P2X3 homotrimers and P2X2/3 heterotrimers with a pIC50 range of 7.3 - 8.5. The compound does not affect other P2X family members at 300-fold excess concentrations. AF-353 significantly reversed pain behavior in a rat model of bone cancer pain.

Features and Benefits

This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

A1612-25MG:
A1612-VAR:
A1612-5MG:
A1612-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
021M4619V

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