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Safety Information

A126

Sigma-Aldrich

(±)-HA-966

Synonym(s):

(±)-3-Amino-1-hydroxy-2-pyrrolidone

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About This Item

Empirical Formula (Hill Notation):
C4H8N2O2
CAS Number:
1003-51-6
Molecular Weight:
116.12
MDL number:
MFCD00069208
UNSPSC Code:
12352200
PubChem Substance ID:
24890516

SMILES string

NC1CCN(O)C1=O

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

A126-VAR:
A126-BULK:
A126-100MG:
A126-25MG:

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Certificates of Analysis (COA)

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Valéria Martinez et al.
Pain, 99(3), 537-545 (2002-10-31)
Systemic opioid dosing until adequate analgesia in neuropathic pain may involve intolerable and untreatable side effects. Peripheral opioid receptor mechanisms may participate in the antinociceptive effect of systemic morphine. We evaluated the effect of peripherally injected morphine alone, and the
Svenja Esther Sander et al.
European journal of pharmacology, 563(1-3), 102-108 (2007-03-14)
Imbalances of the glutamatergic system are implicated in the pathophysiology of various basal ganglia disorders, but few is known about their role in dystonia, a common neurological syndrome in which involuntary muscle co-contractions lead to twisting movements and abnormal postures.
Jaroslava Buritova et al.
European journal of pain (London, England), 7(3), 241-249 (2003-05-03)
The effects of the S enantiomer of RB101, a complete inhibitor of enkephalin-catabolizing enzymes, alone or in combination with a functional NMDA receptor antagonist, (+)-HA966 were studied on the spinal c-Fos protein expression in the carrageenan model of inflammatory nociception.
Frédéric Adam et al.
Neuropharmacology, 51(2), 191-202 (2006-05-23)
N-methyl-D-aspartate (NMDA) receptors are widely involved in opioid tolerance. However, it is less clear whether NMDA receptor antagonists reverse already-established tolerance and whether the intensity of the nociceptive stimulus influences morphine tolerance. Three days after implantation of morphine or control
Long Chen et al.
Journal of neurophysiology, 89(2), 691-703 (2003-02-08)
The N-methyl-D-aspartate (NMDA) receptor (NMDA-R) has pivotal roles in neural development, learning, memory, and synaptic plasticity. Functional impairment of NMDA-R has been implicated in schizophrenia. NMDA-R activation requires glycine to act on the glycine-B (GlyB) site of the NMDA-R as
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