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A0670

Sigma-Aldrich

Anti-Adenosine 3′,5′-Cyclic Monophosphate (cAMP) antibody produced in rabbit

whole antiserum

Synonym(s):

Anti-cAMP

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About This Item

MDL number:
MFCD00162208
UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

wide range

technique(s)

immunohistochemistry: suitable
radioimmunoassay: 1:10

storage temp.

2-8°C

General description

3′5′-Cyclic Adenosine Monophosphate (c-AMP) is an intracellular hormonal mediator that facilitates the glycogenolytic effects of epinephrine and glucagon in the liver. c-AMP is also mediates the effect of several other hormones, and is known to function as a second messenger for intracellular signal transductions.
Anti-Adenosine 3′,5′-Cyclic Monophosphate (cAMP) is specific for cAMP and does not cross-react with 5′-AMP, 5′-ADP, 5′-ATP or 3′,5′-cGMP.

Immunogen

Cyclic AMP-2′-BSA

Application

Anti-Adenosine 3′,5′-Cyclic Monophosphate (cAMP) antibody is suitable for use in radioimmunoassays. It can also be used for immunohistochemical assays.
Rabbit anti-cAMP was used in an enzyme immunoassay to detect the level of cAMP in human CD34+ peripheral blood mononuclear cells. Anti-cAMP was incubated with cells on a microtiter plate at room temperature on a shaker (300 rpm) for 2 hours.

Physical form

The antibody is provided as a pre-diluted antiserum that has been lyophilized.

Reconstitution

Reconstitute with 1ml 0.1% BSA in distilled water. Store the reconstituted stock at -20°C. Working dilution (1:10) to be discarded if unused within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

A0670-BULK:
A0670-VAR:
A0670-100X100TST:
A0670-100TST:
A0670-10X100TST:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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V Asghari et al.
Journal of neurochemistry, 65(3), 1157-1165 (1995-09-01)
To investigate whether polymorphic forms of the human dopamine D4 receptor have different functional characteristics, we have stably expressed cDNAs of the D4.2, D4.4, and D4.7 isoforms in several cell lines. Chinese hamster ovary CHO-K1 cell lines expressing D4 receptor
Qi Cui et al.
Molecular and cellular neurosciences, 22(1), 49-61 (2003-02-22)
In vitro, cyclic AMP (cAMP) elevation alters neuronal responsiveness to diffusible growth factors and myelin-associated inhibitory molecules. Here we used an established in vivo model of adult central nervous system injury to investigate the effects of elevated cAMP on neuronal
I S Liu et al.
American journal of medical genetics, 61(3), 277-282 (1996-01-22)
The D4Valine194Glycine receptor is a variant of the dopamine D4 receptor and is found in 12.5% of the Afro-Caribbean population. Glycine replaces valine at a position one amino acid away from a serine which is critical for the attachment of
Alexandre A Steiner et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 283(6), R1412-R1422 (2002-10-22)
Hypoxia evokes a regulated decrease in body temperature, a response that has been termed anapyrexia, but the mechanisms involved are poorly understood. Therefore, the present study was undertaken to test the hypothesis that hypoxia-induced anapyrexia results from the activation of
Dirk M Lang et al.
The Journal of comparative neurology, 525(4), 936-954 (2016-09-13)
The myelin-associated protein Nogo-A contributes to the failure of axon regeneration in the mammalian central nervous system (CNS). Inhibition of axon growth by Nogo-A is mediated by the Nogo-66 receptor (NgR). Nonmammalian vertebrates, however, are capable of spontaneous CNS axon
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