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Safety Information

94333

Sigma-Aldrich

Uridine 5′-diphosphogalactose disodium salt

≥98.0% (HPLC)

Synonym(s):

UDP-Gal, Uridine-diphosphate-galactose disodium salt, Uridine[5’]diphospho[1]-α-D-galactopyranose disodium salt

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About This Item

Empirical Formula (Hill Notation):
C15H22N2Na2O17P2
CAS Number:
137868-52-1
Molecular Weight:
610.27
Beilstein:
5374254
MDL number:
MFCD00077895
UNSPSC Code:
41106305
PubChem Substance ID:
57653600

Assay

≥98.0% (HPLC)

form

powder

impurities

≤5% solvent (ethanol)
≤6% water

solubility

H2O: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

[Na+].[Na+].OC[C@H]1O[C@@H](OP([O-])(=O)OP([O-])(=O)OC[C@H]2OC([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O)[C@H](O)[C@@H](O)[C@H]1O

InChI

1S/C15H24N2O17P2.2Na/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25;;/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25);;/q;2*+1/p-2/t5-,6-,8+,9-,10+,11-,12-,13?,14?;;/m1../s1

InChI key

PKJQEQVCYGYYMM-OUJOOSCPSA-L

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Application

Uridine 5dATP-diphosphogalactose (UDP-Gal) is a sugar-nucleotide substrate of galactosyltransferase(s) involved in the addition of galatose (galactosylation) molecules to N-linked and O-linked oligosaccharides and glycerolipids. UDP-Gal and its analogues are used to study the distribution, specificity and kinetics of galactosyltransferase(s).

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

94333-VAR:
94333-10MG:
94333-BULK:
94333-50MG:
94333-250MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Karine Descroix et al.
Organic & biomolecular chemistry, 9(6), 1855-1863 (2011-01-27)
Structural analogues and mimics of the natural sugar-nucleotide UDP-galactose (UDP-Gal) are sought after as chemical tools for glycobiology and drug discovery. We have recently developed a novel class of galactosyltransferase (GalT) inhibitors derived from UDP-Gal, bearing an additional substituent at
Eric R Moellering et al.
Trends in plant science, 16(2), 98-107 (2010-12-15)
Galactoglycerolipids are the predominant lipid building blocks of chloroplast membranes and are essential for plant growth. Plant chloroplasts harbor a constitutive set of UDP-Gal-dependent lipid galactosyltransferases that are responsible for the bulk of galactoglycerolipid biosynthesis. A set of paralogs is
Subcellular localization of UDP-GlcNAc, UDP-Gal and SLC35B4 transporters.
Maszczak-Seneczko D, Olczak T, Olczak M.
Acta Biochimica Polonica, 58(3), 416-419 (2011)
Development of IgA nephropathy-like disease with high serum IgA levels and increased proportion of polymeric IgA in β-1,4-galactosyltransferase-deficient mice.
Nishie T, Miyaishi O, Azuma H, et al.
The American Journal of Pathology, 157, 125-128 (2007)
A E Hills et al.
Biotechnology and bioengineering, 75(2), 239-251 (2001-09-06)
Variable N-glycosylation at Asn(297) in the Fc region of recombinant therapeutic immunoglobulin G (IgG) molecules, specifically terminal galactosylation and sialylation, may affect both pharmacokinetic behavior and effector functions of recombinant therapeutic antibodies. We investigated the hypothesis that IgG Fc glycosylation
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