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Safety Information

77739

Sigma-Aldrich

Pefachrome® Fxa

≥95.0% (HPLC)

Synonym(s):

N-Methoxycarbonyl-D-cyclohexylalanyl-glycyl-L-arginine-4-nitroanilide acetate, N-Methoxycarbonyl-D-Cha-Gly-Arg-4-nitroanilide acetate

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About This Item

Empirical Formula (Hill Notation):
C25H38N8O7 · C2H4O2
CAS Number:
80895-10-9
Molecular Weight:
622.67
MDL number:
MFCD03791099
UNSPSC Code:
12352200
PubChem Substance ID:
57652710

Assay

≥95.0% (HPLC)

form

powder

solubility

water: 1 mg/mL, clear, colorless

suitability

degradable with trypsin for enzyme test (substrate for Factor Xa)

storage temp.

2-8°C

SMILES string

CC(O)=O.COC(=O)N[C@H](CC1CCCCC1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)Nc2ccc(cc2)[N+]([O-])=O

InChI

1S/C25H38N8O7.C2H4O2/c1-40-25(37)32-20(14-16-6-3-2-4-7-16)22(35)29-15-21(34)31-19(8-5-13-28-24(26)27)23(36)30-17-9-11-18(12-10-17)33(38)39;1-2(3)4/h9-12,16,19-20H,2-8,13-15H2,1H3,(H,29,35)(H,30,36)(H,31,34)(H,32,37)(H4,26,27,28);1H3,(H,3,4)/t19-,20+;/m0./s1

InChI key

QXWRKXQCMBOLJR-CMXBXVFLSA-N

Application

Pefachrome® substrates are used for chromogenic assays of various serine proteinases. Pefachrome® Fxa is used for the detection of serine proteases such as blood coagulation factor Xa.

Packaging

1 piece contains 10 μmol Pefachrome® FXA

Legal Information

Pefachrome is a registered trademark of Pentapharm AG, Basel

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

77739-1EA-F:
77739-BULK-F:
77739-1EA-BULK-F:
77739-VAR-F:
77739-10UMOL-F:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Marjory B Brooks
Veterinary clinical pathology, 33(4), 208-214 (2004-12-01)
Unfractionated heparin (UFH) has a complex pharmacologic profile that necessitates patient monitoring to prevent inadequate anticoagulation or overdosage and hemorrhage. Factor Xa inhibitory assays (to measure anti-Xa activity) are used to adjust UFH dosage and define safe and effective regimens
An optimised, rapid chromogenic assay, specific for measuring direct factor Xa inhibitors (rivaroxaban) in plasma.
Meyer Michel Samama et al.
Thrombosis and haemostasis, 104(5), 1078-1079 (2010-09-02)
Job Harenberg et al.
Journal of thrombosis and thrombolysis, 32(3), 267-271 (2011-08-04)
Rivaroxaban and other oral direct factor Xa inhibitors (ODiXa) are currently developed for prophylaxis and treatment of thromboembolic diseases using fixed doses. Although routine monitoring is not required, assessing the intensity of anticoagulation may be useful under certain clinical conditions.

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