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42597

Supelco

3′-Deoxythymidine 5′-triphosphate sodium salt solution

BioChemika, puriss. p.a., suitable for MALDI-MS, ≥98.0% (HPLC)

Synonym(s):

2′,3′-Dideoxythymidine 5′-triphosphate, ddTTP

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About This Item

Empirical Formula (Hill Notation):
C10H16N2NaO13P3
CAS Number:
Molecular Weight:
488.15
MDL number:
UNSPSC Code:
41116105
PubChem Substance ID:

product line

BioChemika

grade

puriss. p.a.

Assay

≥98.0% (HPLC)

concentration

10.0-11.0 mmol/L (UV)

technique(s)

MALDI-MS: suitable

impurities

≤1.5% ddNDP (HPLC)

suitability

corresponds for UV test

storage temp.

−20°C

SMILES string

[Na+].CC1=CN([C@H]2CC[C@@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)NC1=O

InChI

1S/C10H17N2O13P3.Na/c1-6-4-12(10(14)11-9(6)13)8-3-2-7(23-8)5-22-27(18,19)25-28(20,21)24-26(15,16)17;/h4,7-8H,2-3,5H2,1H3,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17);/q;+1/p-1/t7-,8+;/m0./s1

InChI key

QJSZKDPCBDXBCK-KZYPOYLOSA-M

General description

3′-Deoxythymidine 5′-triphosphate sodium (ddTTP) is a sugar-modified dTTP analogue which is selective inhibitor of HIV-associated reverse transcriptase (HIV-RT). It is also seen to inhibit the activity of DNA polymerase α.

Packaging

packaging : 1 μmol (approx. 91-100 μL)

related product

Product No.
Description
Pricing

replaced by

Product No.
Description
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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

42597-VAR-F:
42597-1UMO-F:
42597-10UMO-F:
42597-BULK-F:


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jess Tyson et al.
BMC genomics, 10, 453-453 (2009-09-30)
Copy number variation (CNV) in the human genome is recognised as a widespread and important source of human genetic variation. Now the challenge is to screen for these CNVs at high resolution in a reliable, accurate and cost-effective way. Multiplex
Konstantin Akopiants et al.
Nucleic acids research, 42(5), 3125-3137 (2013-12-29)
To track the processing of damaged DNA double-strand break (DSB) ends in vivo, a method was devised for quantitative measurement of 3'-phosphoglycolate (PG) termini on DSBs induced by the non-protein chromophore of neocarzinostatin (NCS-C) in the human Alu repeat. Following
E Matthes et al.
Biochemical and biophysical research communications, 148(1), 78-85 (1987-10-14)
The sugar-modified dTTP analogues 2',3'-didehydro-2',3'-dideoxy-thymidine 5'-triphosphate (ddeTTP), 2',3'-dideoxythymidine 5'-triphosphate (ddTTP), 3'-fluorothymidine 5'-triphosphate (FdTTP), and 3'-azidothymidine 5'-triphosphate (N3dTTP) are demonstrated to be very effective and selective inhibitors of the HIV-associated reverse transcriptase (HIV-RT). This conclusion is based on a comparison of
Elena N Ilina et al.
Frontiers in microbiology, 4, 186-186 (2013-07-13)
Spectinomycin remains a useful reserve option for therapy of gonorrhea. The emergence of multidrug-resistant Neisseria gonorrhoeae strains with decreased susceptibility to cefixime and to ceftriaxone makes it the only medicine still effective for treatment of gonorrhea infection in analogous cases.
Juan Gambini et al.
Antioxidants (Basel, Switzerland), 10(2) (2021-03-07)
The beneficial effects of moderate red wine consumption on cardiovascular health are well known. The composition of red wine includes several compounds, such as the phytoestrogen resveratrol, that exert these beneficial effects, although not all the mechanisms by which they

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