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Merck
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Key Documents

Safety Information

363R-3

Sigma-Aldrich

PAX-8 (SP348) Rabbit Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203

biological source

rabbit blood

Quality Level

500

conjugate

unconjugated

antibody form

IgG fraction of tissue culture supernatant

antibody product type

primary antibodies

clone

SP348

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL (concentrate (363R-34-RUO) Research Use Only)
vial of 0.1 mL
(concentrate (363R-34))
vial of 0.5 mL (concentrate (363R-35))
vial of 1.0 mL (concentrate (363R-36))
vial of 1.0 mL (concentrate (363R-36-RUO) Research Use Only)
vial of 1.0 mL (pre-dilute (363R-37-RUO) Research Use Only)
vial of 1.0 mL (pre-dilute ready-to-use (363R-37))
vial of 25.0 mL (pre-dilute ready-to-use (363R-30))
vial of 25.0 mL (pre-dilute ready-to-use (363R-30-RUO))
vial of 7.0 mL (pre-dilute ready-to-use (363R-38))
vial of 7.0 mL (pre-dilute ready-to-use (363R-38-RUO) Research Use Only)

manufacturer/tradename

Cell Marque™

technique(s)

immunocytochemistry: suitable (formalin-fixed, paraffin-embedded sections 1:10-1:20 (concentrated))

isotype

IgG

control

ovarian carcinoma, papillary carcinoma of thyroid, renal cell carcinoma, (Fallopian Tube)

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

General description

PAX-8 is a transcription factor expressed during embryonic development of Müllerian organs, kidney, and thyroid, with continued expression in neoplastic transformation of some epithelial cell types of these mature tissues.1 It can be useful for marking several types of carcinoma including, but not limited to, ovarian serous carcinoma, clear cell renal cell carcinoma and papillary thyroid carcinoma. Certain anti-PAX-8 antibodies may react with lymphocytes and their neoplasms, which has been attributed to cross-reactivity with PAX-5 due to sequence homology between PAX-8 and PAX-5, but clone SP348 does not exhibit reactivity in these cell types.

Quality

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

363R-34:
363R-30:
363R-38:
363R-37:
363R-35:
363R-36:

Certificates of Analysis (COA)

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Lucas Moretti et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 25(2), 231-236 (2011-11-01)
Recently, reports using immunohistochemistry and a polyclonal antibody directed against the N-terminal region of PAX8 describe PAX8 expression in malignant lymphomas. As the N-terminal regions of PAX family members, including the B-cell transcription factor PAX5, have high sequence homology, we
Ayhan Ozcan et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 24(6), 751-764 (2011-02-15)
PAX 8 is a transcription factor that is essential for embryonic development of the kidney, Müllerian organs, and thyroid. It may also have a role in tumor development in these organs. The diagnostic utility of PAX 8 has not been
Daisuke Nonaka et al.
The American journal of surgical pathology, 32(10), 1566-1571 (2008-08-30)
The ovary is a common site of involvement for metastasis and the breast is one of the most common sources. Metastatic breast carcinoma can mimic a primary ovarian carcinoma. Pax8 is a crucial transcription factor for organogenesis of the thyroid
Daisuke Nonaka et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21(2), 192-200 (2007-12-18)
Thyroid-specific transcription factors, Pax8, TTF-1, and TTF-2, are crucial for thyroid organogenesis and differentiation. Compared with TTF-1, the other two markers have scarcely been investigated in surgical pathology. The goal of this study is to evaluate the expressions of these
Guo-Xia Tong et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 22(9), 1218-1227 (2009-06-16)
Cell-lineage-specific transcription factors are a group of regulatory proteins expressed in embryonic, differentiated, or neoplastic cells of the same lineage and represent a valuable repertoire of tissue-specific markers for the diagnosis of human tumors. Together with PAX2, PAX8 is a
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