04497
Phalloidin–Atto 665
suitable for fluorescence, ≥90% (HPLC)
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| Size/SKU | Availability | Price |
|---|---|---|
10 nmol | Check Cart for Availability | ¥103,000 |
About This Item
Quality Segment
assay
≥90% (HPLC)
manufacturer/tradename
ATTO-TEC GmbH
fluorescence
λex 663 nm; λem 684 nm in 0.1 M phosphate pH 7.0
suitability
suitable for fluorescence
storage temp.
−20°C
General description
Phalloidin is a fungal toxin isolated from the poisonous mushroom Amanita phalloides. Its toxicity is attributed to the ability to bind F actin in liver and muscle cells. As a result of binding phalloidin, actin filaments become strongly stabilized. Phalloidin has been found to bind only to polymeric and oligomeric forms of actin, and not to monomeric actin. The dissociation constant of the actin-phalloidin complex has been determined to be on the order of 3 x 10-8. Phalloidin differs from amanitin in rapidity of action; at high dose levels, death of mice or rats occurs within 1 or 2 hours. Fluorescent conjugates of phalloidin are used to label actin filaments for histological applications. Some structural features of phalloidin are required for the binding to actin. However, the side chain of amino acid 7 (g-d-dihydroxyleucine) is accessible for chemical modifications without appreciable loss of affinity for actin.
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Legal Information
1 of 1
This Item | |||
|---|---|---|---|
| suitability suitable for fluorescence | suitability suitable for fluorescence | suitability suitable for fluorescence | suitability suitable for fluorescence |
| fluorescence λex 663 nm; λem 684 nm in 0.1 M phosphate pH 7.0 | fluorescence - | fluorescence λex 663 nm; λem 684 nm in 0.1 M phosphate pH 7.0 | fluorescence λex 594 nm; λem 624 nm in 0.1 M phosphate pH 7.0 |
| assay ≥90% (HPLC) | assay ≥80.0% (HPLC) | assay ≥90.0% (sum of isomers, HPLC) | assay ≥90% |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| manufacturer/tradename ATTO-TEC GmbH | manufacturer/tradename ATTO-TEC GmbH | manufacturer/tradename ATTO-TEC GmbH | manufacturer/tradename ATTO-TEC GmbH |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
04497-10NMOL:
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