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C0980650

Cetirizine dihydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C21H25ClN2O3 · 2HCl
CAS Number:
83881-52-1
Molecular Weight:
461.81
MDL number:
MFCD00941428
UNSPSC Code:
41116107
PubChem Substance ID:
329774831
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

cetirizine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

OC(COCCN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1)=O.[H]Cl.[H]Cl

InChI

1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H

InChI key

PGLIUCLTXOYQMV-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Cetirizine dihydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Cetirizine hydrochloride is an orally active and selective H1-receptor antagonist. Antihistaminic; Piperazines. Non-sedating type histamine H1-receptor antagonist; major metabolite of hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Description
Pricing

C0980651

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Y0001197

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1102929

Cetirizine dihydrochloride, United States Pharmacopeia (USP) Reference Standard

1102930

Cetirizine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1112467

4-Chlorobenzophenone, United States Pharmacopeia (USP) Reference Standard

1102952

Cetirizine Related Compound C, United States Pharmacopeia (USP) Reference Standard

1102941

Cetirizine Related Compound B, United States Pharmacopeia (USP) Reference Standard

PHR1710

Cetirizine hydrochloride Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

1102963

Cetirizine Related Compound G, United States Pharmacopeia (USP) Reference Standard

BP837

Cetirizine hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP1081

Cetirizine impurity standard, British Pharmacopoeia (BP) Reference Standard

BP441

1,4-Bis(4-chlorobenzhydryl)piperazine, British Pharmacopoeia (BP) Reference Standard

PHR2620

4-Chlorobenzophenone, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2852

Cetirizine Related Compound G, certified reference material, pharmaceutical secondary standard

PHR3195

Levocetirizine Dihydrochloride, pharmaceutical secondary standard, certified reference material

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

C0980650-100MG:
C0980650:
C0980650-1EA:

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Arnold Bahlmann et al.
Chemosphere, 89(11), 1278-1286 (2012-06-12)
Carbamazepine (CBZ), caffeine and cetirizine were monitored by enzyme-linked immunosorbent assays (ELISAs) in surface and wastewaters from Berlin, Germany. This fast and cost-efficient method enabled to assess the spatial and temporal variation of these anthropogenic markers in a high-throughput screening.
Ko-Haung Lue et al.
International journal of pediatric otorhinolaryngology, 76(7), 994-1001 (2012-04-20)
Supplementary consumption of probiotics may temporarily alter the intestinal microflora of infants and children, thereby preventing and treating allergic disorders. To compare the clinical efficacy of levocetirizine with that of levocetirizine plus Lactobacillus johnsonii EM1 (Lj EM1) for treating perennial
Macheng Yan et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 33(1), 60-64 (2013-04-20)
To investigate the potential rules and knowledge of Traditional Chinese Medicine (TCM) and Western Medicine (WM) treatment on chronic urticaria (CU) based on data-mining methods. Sixty patients with chronic urticaria, treated with TCM and WM, were selected. Gray correlation analyses
Natalie J Carter
Drugs, 72(9), 1257-1269 (2012-06-13)
Bilastine is an orally administered, second-generation antihistamine used in the symptomatic treatment of seasonal or perennial allergic rhinoconjunctivitis and urticaria. In two well designed phase III trials, 14 days' treatment with bilastine was associated with a significantly lower area under
Susan D Mathias et al.
Allergy and asthma proceedings, 33(2), 186-190 (2012-04-25)
The Urticaria Patient Daily Diary, including the Urticaria Activity Score, has recently been validated in adults with chronic idiopathic urticaria (CIU), but its validity in adolescents is unknown. This study was designed to (1) assess the content validity of the
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