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BP421

Ethinylestradiol

British Pharmacopoeia (BP) Assay Standard

Synonym(s):

17α-Ethynylestradiol, 17α-Ethynyl-1,3,5(10)-estratriene-3,17β-diol, 19-Nor-1,3,5(10),17α-pregnatrien-20-yne-3,17-diol, Ethinylestradiol

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About This Item

Empirical Formula (Hill Notation):
C20H24O2
CAS Number:
57-63-6
Molecular Weight:
296.40
Beilstein:
2419975
EC Number:
200-342-2
MDL number:
MFCD00003690
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

ethinyl estradiol

form

solid

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

mp

182-183 °C (lit.)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

storage temp.

2-8°C

SMILES string

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)C#C)[C@]1([H])CCc4cc(O)ccc24

InChI

1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1

InChI key

BFPYWIDHMRZLRN-SLHNCBLASA-N

Gene Information

human ... ESR1(2099)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ethinylestradiol BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Co-cyprindiol Tablets
  • Levonorgestrel Tablets
  • Norgestrel Tablets
  • Levonorgestrel and Ethinylestradiol Tablets
  • Ethinylestradiol Tablets

    • Other Notes

    Sales restrictions may apply.

    Signal Word

    Danger

    Hazard Statements

    H302,H351,H360Fd,H410

    Hazard Classifications

    Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 2 - Repr. 1A

    Storage Class Code

    6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

    WGK

    WGK 3

    Regulatory Listings

    Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

    JAN Code

    BP421-100MG:
    BP421:

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    Certificates of Analysis (COA)

    Lot/Batch Number

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    Marie Louise Wissing et al.
    Journal of ovarian research, 7, 110-110 (2014-11-30)
    Corona radiata cells (CRCs) refer to the fraction of cumulus cells just adjacent to the oocyte. The CRCs are closely connected to the oocyte throughout maturation and their gene expression profiles might reflect oocyte quality. Polycystic ovary syndrome (PCOS) is
    Andrew M Kaunitz et al.
    Obstetrics and gynecology, 123(2 Pt 1), 295-303 (2014-01-10)
    To compare a new low-dose levonorgestrel and ethinyl estradiol contraceptive patch (Patch) with a combination oral contraceptive (Pill; 100 micrograms levonorgestrel, 20 micrograms ethinyl estradiol) regarding efficacy, safety, compliance, and unscheduled uterine bleeding. Women (17-40 years; body mass index 16-60)
    Gregory Brazzola et al.
    Evolutionary applications, 7(9), 1084-1093 (2015-01-02)
    The evolutionary potential of natural populations to adapt to anthropogenic threats critically depends on whether there exists additive genetic variation for tolerance to the threat. A major problem for water-dwelling organisms is chemical pollution, and among the most common pollutants
    Matteo Morotti et al.
    European journal of obstetrics, gynecology, and reproductive biology, 183, 178-182 (2014-12-03)
    To evaluate the effect of a desogestrel progestogen-only pill (POP) compared to continuous combined oral contraception (COC) on migraine patterns in women with migraine without aura. A retrospective analysis of prospective headache charts from migrainous women who used the POP
    Christoph Kapitza et al.
    Journal of clinical pharmacology, 55(5), 497-504 (2014-12-06)
    The effect of semaglutide, a once-weekly human glucagon-like peptide-1 (GLP-1) analog in development for type 2 diabetes (T2D), on the bioavailability of a combined oral contraceptive was investigated. Postmenopausal women with T2D (n = 43) on diet/exercise ± metformin received ethinylestradiol (0.03 mg)/levonorgestrel (0.15 mg) once
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