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Safety Information

93630

Sigma-Aldrich

Trypsin, TPCK treated, from bovine pancreas

~7500 U/mg

Synonym(s):

TPCK-Trypsin

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About This Item

CAS Number:
9002-07-7
Enzyme Commission number:
3.4.21.4 (BRENDA, IUBMB)
EC Number:
232-650-8
MDL number:
MFCD00082094
UNSPSC Code:
12352204

specific activity

~7500 U/mg

shipped in

wet ice

storage temp.

−20°C

Unit Definition

1 U corresponds to the amount of enzyme which increases the absorbance at 253 nm by 0.001 per minute at pH 7.6 and 25°C (N-benzoyl-L-arginine ethyl ester, Cat. No. 12880, as substrate)

Other Notes

Sales restrictions may apply
TPCK-treatment irreversibly inhibits the chymotrypsin-activity without affecting the trypsin-activity; Application in (selective) hydrolysis/condensation of amide bonds; Tryptic degradation of opioid peptide precursors in rat brain

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H315,H319,H334,H335

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

93630-VAR:
93630-25MG:
93630-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
039624/2
039624-442
39624/2
39624/1
039624/1

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G Q Zhang et al.
Chemical & pharmaceutical bulletin, 39(9), 2369-2372 (1991-09-01)
A high-performance liquid chromatographic method involving postcolumn fluorescence derivatization is described for the quantification of five fragment peptides (methionine-enkephalin-Thr-Ser-Glu-Lys, methionine-enkephalin-Lys, methionine-enkephalin-Arg, leucine-enkephalin-Lys and leucine-enkephalin-Arg) released by tryptic digestion from the opioid peptide precursors (proopiomeranocortin and proenkephalins A and B) in
A. Florsheimer et al.
Monatshefte fur Chemie / Chemical Monthly, 119, 1323-1323 (1988)
Direct evidence for the presence of histidine in the active center of chymotrypsin.
G SCHOELLMANN et al.
Biochemistry, 2, 252-255 (1963-03-01)

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