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916889

Sigma-Aldrich

tert-Butyl 4-(4-(2-aminoethyl)phenyl)piperidine-1-carboxylate

≥95%

Synonym(s):

Semi-flexible linker for PROTAC® development

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About This Item

Empirical Formula (Hill Notation):
C18H28N2O2
CAS Number:
1402667-19-9
Molecular Weight:
304.43
UNSPSC Code:
12352116

Quality Level

100

Assay

≥95%

form

powder

reaction suitability

reagent type: linker

functional group

Boc
amine

storage temp.

2-8°C

SMILES string

O=C(N(CC1)CCC1C(C=C2)=CC=C2CCN)OC(C)(C)C

Application

tert-Butyl 4-(4-(2-aminoethyl)phenyl)piperidine-1-carboxylate is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Description
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2-(4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid, ≥95%

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tert-Butyl 4-(4-(hydroxymethyl)phenyl)piperidine-1-carboxylate, ≥95%

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2-(3-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid

917869

2-(2-(Piperidin-4-yl)phenyl)acetic acid hydrochloride, ≥95%

916870

4-(1-(tert-butoxycarbonyl)piperidin-4-yl)benzoic acid, ≥95%

916617

2-(3-(Piperidin-4-yl)phenyl)acetic acid hydrochloride, ≥95%

916633

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917591

tert-Butyl 4-(3-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate, ≥95%

916900

2-(3-(Piperidin-4-yl)phenyl)ethan-1-ol hydrochloride, ≥95%

916641

2-(3-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride, 95%

917648

(4-(Piperidin-4-yl)phenyl)methanol hydrochloride, ≥95%

916854

2-(Piperidin-4-yl)benzoic acid hydrochloride, 95%

917907

2-(4-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride, ≥95%

917095

4-(Piperidin-4-yl)benzoic acid hydrochloride, ≥95%

917893

(2-(Piperidin-4-yl)phenyl)methanol hydrochloride, ≥95%

917656

3-(Piperidin-4-yl)benzoic acid hydrochloride, ≥95%

917168

tert-Butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate, ≥95%

917397

(2-(Piperidin-4-yl)phenyl)methanamine dihydrochloride

917419

2-(2-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride

917354

tert-Butyl 4-(4-(aminomethyl)phenyl)piperidine-1-carboxylate

917141

2-(4-(Piperidin-4-yl)phenyl)ethan-1-ol hydrochloride, ≥95%

916625

tert-Butyl 4-(3-(2-aminoethyl)phenyl)piperidine-1-carboxylate, ≥95%

917915

2-(2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid, ≥95%

917133

(4-(Piperidin-4-yl)phenyl)methanamine dihydrochloride, ≥95%

917400

tert-Butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate, ≥95%

917664

2-(2-(Piperidin-4-yl)phenyl)ethan-1-ol hydrochloride, ≥95%

916897

(3-(Piperidin-4-yl)phenyl)methanol hydrochloride, ≥95%

916846

2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid, 95%

916595

tert-Butyl 4-(4-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate, ≥95%

916587

3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid, ≥95%

917850

tert-Butyl 4-(2-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate, ≥95%

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

916889-BULK:
916889-100MG:
916889-VAR:

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