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Safety Information

87371

Sigma-Aldrich

Tetrahydrofuran

absolute, over molecular sieve (H2O ≤0.005%), contains ~0.025% 2,6-di-tert-butyl-4-methylphenol as stabilizer, ≥99.5% (GC)

Synonym(s):

Butylene oxide, Oxolane, Tetramethylene oxide

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About This Item

Empirical Formula (Hill Notation):
C4H8O
CAS Number:
Molecular Weight:
72.11
Beilstein:
102391
EC Number:
MDL number:
UNSPSC Code:
12191501
PubChem Substance ID:

vapor density

2.5 (vs air)

vapor pressure

114 mmHg ( 15 °C)
143 mmHg ( 20 °C)

grade

absolute

Assay

≥99.5% (GC)

autoignition temp.

610 °F

quality

over molecular sieve (H2O ≤0.005%)

contains

~0.025% 2,6-di-tert-butyl-4-methylphenol as stabilizer

expl. lim.

1.8-11.8 %

impurities

≤0.005% (water)

refractive index

n20/D 1.407 (lit.)

bp

65-67 °C (lit.)

mp

−108 °C (lit.)

density

0.889 g/mL at 25 °C (lit.)

SMILES string

C1CCOC1

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

InChI key

WYURNTSHIVDZCO-UHFFFAOYSA-N

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Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

-6.2 °F - closed cup

Flash Point(C)

-21.2 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 1 petroleums
Hazardous rank II
Water soluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

87371-BULK:
87371-6X1L:4548173274027
87371-2.5L:4548173182216
87371-4X2.5L:4548173274010
87371-VAR:
87371-250ML:4548173182223
87371-1L:4548173182209


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Olav Schiemann et al.
Nature protocols, 2(4), 904-923 (2007-04-21)
In this protocol, we describe the facile synthesis of the nitroxide spin-label 2,2,5,5-tetramethyl-pyrrolin-1-oxyl-3-acetylene (TPA) and then its coupling to DNA/RNA through Sonogashira cross-coupling during automated solid-phase synthesis. Subsequently, we explain how to perform distance measurements between two such spin-labels on
Synthetic routes to tetrahydrofuran, tetrahydropyran, and spiroketal units of polyether antibiotics and a survey of spiroketals of other natural products.
Boivin TLB.
Tetrahedron, 43(15), 3309-3362 (1987)
Eagleson M.
Concise Encyclopedia Chemistry, 883-883 (1994)
Eagleson M.
Concise Encyclopedia Chemistry, 152-152 (1994)
Polyhedral clathrate hydrates. X. Structure of the double hydrate of tetrahydrofuran and hydrogen sulfide.
Mak TCW, et al.
J. Chem. Phys. , 42(8), 2732-2737 (1965)

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